Free Access
Med Sci (Paris)
Volume 31, Number 3, Mars 2015
Page(s) 275 - 281
Section M/S Revues
Published online 08 April 2015
  1. O’Dowd BF, Heiber M, Chan A, et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 1993 ; 136 : 355–360. [CrossRef] [PubMed] [Google Scholar]
  2. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998 ; 251 : 471–476. [CrossRef] [PubMed] [Google Scholar]
  3. Galanth C, Hus-Citharel A, Li B, Llorens-Cortes C. Apelin in the control of body fluid homeostasis and cardiovascular functions. Curr Pharm Des 2012 ; 18 : 789–798. [CrossRef] [PubMed] [Google Scholar]
  4. Llorens-Cortes C, Beaudet A. L’apéline, un inhibiteur naturel de l’effet antidiurétique de la vasopressine. Med Sci (Paris) 2005 ; 21 : 741–746. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  5. Masri B, Lahlou H, Mazarguil H, et al. Apelin (65–77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun 2002 ; 290 : 539–545. [CrossRef] [PubMed] [Google Scholar]
  6. Masri B, Morin N, Pedebernade L, et al. The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments. J Biol Chem 2006 ; 281 : 18317–18326. [CrossRef] [PubMed] [Google Scholar]
  7. Szokodi I, Tavi P, Foldes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 2002 ; 91 : 434–440. [CrossRef] [PubMed] [Google Scholar]
  8. Yue P, Jin H, Xu S, et al. Apelin decreases lipolysis via G(q), G(i), and AMPK-dependent mechanisms. Endocrinology 2011 ; 152 : 59–68. [CrossRef] [PubMed] [Google Scholar]
  9. O’Carroll AM, Lolait SJ, Harris LE, Pope GR. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol 2013 ; 219 : R13–R35. [CrossRef] [PubMed] [Google Scholar]
  10. Dray C, Knauf C, Daviaud D, et al. Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab 2008 ; 8 : 437–445. [CrossRef] [PubMed] [Google Scholar]
  11. Attane C, Daviaud D, Dray C, et al. Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo. J Mol Endocrinol 2011 ; 46 : 21–28. [CrossRef] [PubMed] [Google Scholar]
  12. Attane C, Foussal C, Le Gonidec S, et al. Apelin treatment increases complete fatty acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes 2012 ; 61 : 310–320. [CrossRef] [PubMed] [Google Scholar]
  13. Dray C, Sakar Y, Vinel C, et al. The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. Gastroenterology 2013 ; 144 : 771–780. [CrossRef] [PubMed] [Google Scholar]
  14. Than A, Cheng Y, Foh LC, et al. Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways. Mol Cell Endocrinol 2012 ; 362 : 227–241. [CrossRef] [PubMed] [Google Scholar]
  15. Lee DK, Ferguson SS, George SR, O’Dowd BF. The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Biochem Biophys Res Commun 2010 ; 395 : 185–189. [CrossRef] [PubMed] [Google Scholar]
  16. Zhou N, Fang J, Acheampong E, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology 2003 ; 312 : 196–203. [CrossRef] [PubMed] [Google Scholar]
  17. Scimia MC, Hurtado C, Ray S, et al. APJ acts as a dual receptor in cardiac hypertrophy. Nature 2012 ; 488 : 394–398. [CrossRef] [PubMed] [Google Scholar]
  18. Siddiquee K, Hampton J, McAnally D, et al. The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition. Br J Pharmacol 2013 ; 168 : 1104–1117. [CrossRef] [PubMed] [Google Scholar]
  19. Chun HJ, Ali ZA, Kojima Y, et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 2008 ; 118 : 3343–3354. [PubMed] [Google Scholar]
  20. Sun X, Iida S, Yoshikawa A, et al. Non-activated APJ suppresses the angiotensin II type 1 receptor, whereas apelin-activated APJ acts conversely. Hypertens Res 2011 ; 34 : 701–706. [CrossRef] [PubMed] [Google Scholar]
  21. Cheng SC, Ho L, Tian J, Reversade B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell 2013 ; 27 : 672–680. [CrossRef] [PubMed] [Google Scholar]
  22. Pauli A, Norris ML, Valen E, et al. Toddler: an embryonic signal that promotes cell movement via apelin receptors. Science 2014 ; 343 : 1248636. [CrossRef] [PubMed] [Google Scholar]
  23. Khan P, Maloney PR, Hedrick M, et al. Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program, Bethesda (MD), 2010. [Google Scholar]
  24. Macaluso NJ, Pitkin SL, Maguire JJ, et al. Discovery of a competitive apelin receptor (APJ) antagonist. Chem Med Chem 2011 ; 6 : 1017–1023. [CrossRef] [Google Scholar]
  25. Iturrioz X, Alvear-Perez R, De Mota N, et al. Identification and pharmacological properties of E339–3D6, the first nonpeptidic apelin receptor agonist. FASEB J 2010 ; 24 : 1506–1517. [CrossRef] [PubMed] [Google Scholar]
  26. Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 2005 ; 146 : 1764–1771. [CrossRef] [PubMed] [Google Scholar]
  27. Sorhede Winzell M, Magnusson C, Ahren B. The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept 2005; 131 : 12–17. [CrossRef] [PubMed] [Google Scholar]
  28. Ringstrom C, Nitert MD, Bennet H, et al. Apelin is a novel islet peptide. Regul Pept 2010 ; 162 : 44–51. [CrossRef] [PubMed] [Google Scholar]
  29. Duparc T, Colom A, Cani PD, et al. Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal 2011 ; 15 : 1477–1496. [CrossRef] [PubMed] [Google Scholar]
  30. Yue P, Jin H, Aillaud M, et al. Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab 2010 ; 298 : E59–E67. [CrossRef] [PubMed] [Google Scholar]
  31. Xu S, Han P, Huang M, et al. In vivo, ex vivo, and in vitro studies on apelin’s effect on myocardial glucose uptake. Peptides 2012 ; 37 : 320–326. [CrossRef] [PubMed] [Google Scholar]
  32. Drougard A, Duparc T, Brenachot X, et al. Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes. Antioxid Redox Signal 2014 ; 20 : 557–573. [CrossRef] [PubMed] [Google Scholar]
  33. Yamamoto T, Habata Y, Matsumoto Y, et al. Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle. Biochim Biophys Acta 2011 ; 1810 : 853–862. [CrossRef] [PubMed] [Google Scholar]
  34. Sawane M, Kajiya K, Kidoya H, et al. Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity. Diabetes 2013 ; 62 : 1970–1980. [CrossRef] [PubMed] [Google Scholar]
  35. Dray C, Debard C, Jager J, et al. Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab 2010 ; 298 : E1161–E1169. [CrossRef] [PubMed] [Google Scholar]
  36. Bertrand C, Pignalosa A, Wanecq E, et al. Effects of dietary eicosapentaenoic acid (EPA) supplementation in high-fat fed mice on lipid metabolism and apelin/APJ system in skeletal muscle. PLoS One 2013 ; 8 : e78874. [CrossRef] [PubMed] [Google Scholar]
  37. Castan-Laurell I, Vitkova M, Daviaud D, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol 2008 ; 158 : 905–910. [CrossRef] [PubMed] [Google Scholar]
  38. Besse-Patin A, Montastier E, Vinel C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Int J Obes (Lond) 2014 ; 38 : 707–713. [CrossRef] [PubMed] [Google Scholar]
  39. Kniazeff J, Pin JP. Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ?. Med sci (Paris) 2012 ; 10 : 858–864. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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