Pathogénie du syndrome néphrotique à lesions glomérulaires minimes

Vincent Audard; Philippe Lang; Dil Sahali

doi:10.1051/medsci/20082410853

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Volume 24 / Numéro 10 (Octobre 2008)

Med Sci (Paris), 24 10 (2008) 853-858

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Numéro		Med Sci (Paris) Volume 24, Numéro 10, Octobre 2008


Page(s)		853 - 858
Section		M/S revues
DOI		https://doi.org/10.1051/medsci/20082410853
Publié en ligne		15 octobre 2008

Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006; 354 : 1387–401. [Google Scholar]
Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003; 83 : 253–307. [Google Scholar]
Deen WM. What determines glomerular capillary permeability ? J Clin Invest 2004; 114 : 1412–4. [Google Scholar]
Ali AA, Wilson E, Moorhead JF, et al. Minimal-change glomerular nephritis. Normal kidneys in an abnormal environment ? Transplantation 1994; 58 : 849–52. [Google Scholar]
Rea R, Smith C, Sandhu K, Kwan J, et al. Successful transplant of a kidney with focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16 : 416–7. [Google Scholar]
Feld SM, Savin V, Nast CC, et al. Plasmapheresis in the treatment of steroid-resistant local segmental glomerulosclerosis in native kidneys. Am J Kidney Dis 1998; 32 : 230–7. [Google Scholar]
Ginsburg DS, Dau P. Plasmapheresis in the treatment of steroid-resistant focal segmental glomerulosclerosis. Clin Nephrol 1997; 48 : 282–7. [Google Scholar]
Lagrue G, Branellec A, Blanc C, et al. A vascular permeability factor in lymphocyte culture supernants from patients with nephrotic syndrome. II. Pharmacological and physicochemical properties. Biomedicine 1975; 23 : 73–5. [Google Scholar]
Boulton J, JM, Tulloch I, et al. Changes in the glomerular capillary wall induced by lymphocyte products and serum of nephrotic patients. Clin Nephrol 1983; 20 : 72–7. [Google Scholar]
Tanaka R, Yoshikawa N, Nakamura H, et al. Infusion of peripheral blood mononuclear cell products from nephrotic children increases albuminuria in rats. Nephron 1992; 60 : 35–41. [Google Scholar]
Koyama A, Fujisaki M, Kobayashi M, et al. A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 1991; 40 : 453–60. [Google Scholar]
Lagrue G, Branellec A, Niaudet P, et al. Transmission of nephrotic syndrome to two neonates. Spontaneous regression. Presse Med 1991; 20 : 255–7. [Google Scholar]
Kemper MJ, Wolf G, Muller-Wiefel DE. Transmission of glomerular permeability factor from a mother to her child. N Engl J Med 2001; 344 : 386–7. [Google Scholar]
Valanciute A, le Gouvello S, Solhonne B, et al. NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome. J Immunol 2004; 172 : 688–98. [Google Scholar]
Herve C, Le Berre L, Miqueu P, et al. Blood T-cell repertoire in idiopathic nephrotic syndrome recurrence following kidney transplantation. Am J Transplant 2006; 6 : 2144–51. [Google Scholar]
Neuhaus TJ, Shah V, Callard, RE, Barratt TM. T-lymphocyte activation in steroid-sensitive nephrotic syndrome in childhood. Nephrol Dial Transplant 1995; 10 : 1348–52. [Google Scholar]
Yan K, Nakahara K, Awa S, et al. The increase of memory T cell subsets in children with idiopathic nephrotic syndrome. Nephron 1998; 79 : 274–8. [Google Scholar]
Fodor P, Saitua MT, Rodriguez E, et al. T-cell dysfunction in minimal-change nephrotic syndrome of childhood. Am J Dis Child 1982; 136 : 713–7. [Google Scholar]
Matsumoto K, Osakabe K, Katayama H, et al. Defective cell-mediated immunity in lipoid nephrosis. Int Arch Allergy Appl Immunol 1984; 73 : 370–2. [Google Scholar]
Francois H, Daugas E, Bensman A, Ronco P. Unexpected efficacy of rituximab in multirelapsing minimal change nephrotic syndrome in the adult: first case report and pathophysiological considerations. Am J Kidney Dis 2007; 49 : 158–61. [Google Scholar]
Reiser J, von Gersdorff G, Loos M, et al Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004; 113 : 1390–7. [Google Scholar]
Kestila M, Lenkkeri U, Mannikko M, et al. Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1 : 575–82. [Google Scholar]
Jones N, Blasutig IM, Eremina V, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006; 440 : 818–23. [Google Scholar]
Verma R, Kovari I, Soofi A, et al. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 2006; 116 : 1346–59. [Google Scholar]
Verma R, Wharram B, Kovari I, et al. Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 2003; 278 : 20716–23. [Google Scholar]
Li H, Lemay S, Aoudjit L, et al. SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. J Am Soc Nephrol 2004; 15 : 3006–15. [Google Scholar]
Quack I, Rump LC, Gerke P, et al. beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity. Proc Natl Acad Sci USA 2006; 103 : 14110–5. [Google Scholar]
Huber TB, Hartleben B, Kim J, et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol 2003; 23 : 4917–28. [Google Scholar]
Chen M, She H, Davis E, et al. Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. J Biol Chem 1998; 273 : 25171–8. [Google Scholar]
Done SC, Takemoto M, He L, et al. Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int 2008; 73 : 697–704. [Google Scholar]

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[1] Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006; 354 : 1387–401. [Google Scholar]

[2] Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003; 83 : 253–307. [Google Scholar]

[3] Deen WM. What determines glomerular capillary permeability ? J Clin Invest 2004; 114 : 1412–4. [Google Scholar]

[4] Ali AA, Wilson E, Moorhead JF, et al. Minimal-change glomerular nephritis. Normal kidneys in an abnormal environment ? Transplantation 1994; 58 : 849–52. [Google Scholar]

[5] Rea R, Smith C, Sandhu K, Kwan J, et al. Successful transplant of a kidney with focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 16 : 416–7. [Google Scholar]

[6] Feld SM, Savin V, Nast CC, et al. Plasmapheresis in the treatment of steroid-resistant local segmental glomerulosclerosis in native kidneys. Am J Kidney Dis 1998; 32 : 230–7. [Google Scholar]

[7] Ginsburg DS, Dau P. Plasmapheresis in the treatment of steroid-resistant focal segmental glomerulosclerosis. Clin Nephrol 1997; 48 : 282–7. [Google Scholar]

[8] Lagrue G, Branellec A, Blanc C, et al. A vascular permeability factor in lymphocyte culture supernants from patients with nephrotic syndrome. II. Pharmacological and physicochemical properties. Biomedicine 1975; 23 : 73–5. [Google Scholar]

[9] Boulton J, JM, Tulloch I, et al. Changes in the glomerular capillary wall induced by lymphocyte products and serum of nephrotic patients. Clin Nephrol 1983; 20 : 72–7. [Google Scholar]

[10] Tanaka R, Yoshikawa N, Nakamura H, et al. Infusion of peripheral blood mononuclear cell products from nephrotic children increases albuminuria in rats. Nephron 1992; 60 : 35–41. [Google Scholar]

[11] Koyama A, Fujisaki M, Kobayashi M, et al. A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 1991; 40 : 453–60. [Google Scholar]

[12] Lagrue G, Branellec A, Niaudet P, et al. Transmission of nephrotic syndrome to two neonates. Spontaneous regression. Presse Med 1991; 20 : 255–7. [Google Scholar]

[13] Kemper MJ, Wolf G, Muller-Wiefel DE. Transmission of glomerular permeability factor from a mother to her child. N Engl J Med 2001; 344 : 386–7. [Google Scholar]

[14] Valanciute A, le Gouvello S, Solhonne B, et al. NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome. J Immunol 2004; 172 : 688–98. [Google Scholar]

[15] Herve C, Le Berre L, Miqueu P, et al. Blood T-cell repertoire in idiopathic nephrotic syndrome recurrence following kidney transplantation. Am J Transplant 2006; 6 : 2144–51. [Google Scholar]

[16] Neuhaus TJ, Shah V, Callard, RE, Barratt TM. T-lymphocyte activation in steroid-sensitive nephrotic syndrome in childhood. Nephrol Dial Transplant 1995; 10 : 1348–52. [Google Scholar]

[17] Yan K, Nakahara K, Awa S, et al. The increase of memory T cell subsets in children with idiopathic nephrotic syndrome. Nephron 1998; 79 : 274–8. [Google Scholar]

[18] Fodor P, Saitua MT, Rodriguez E, et al. T-cell dysfunction in minimal-change nephrotic syndrome of childhood. Am J Dis Child 1982; 136 : 713–7. [Google Scholar]

[19] Matsumoto K, Osakabe K, Katayama H, et al. Defective cell-mediated immunity in lipoid nephrosis. Int Arch Allergy Appl Immunol 1984; 73 : 370–2. [Google Scholar]

[20] Francois H, Daugas E, Bensman A, Ronco P. Unexpected efficacy of rituximab in multirelapsing minimal change nephrotic syndrome in the adult: first case report and pathophysiological considerations. Am J Kidney Dis 2007; 49 : 158–61. [Google Scholar]

[21] Reiser J, von Gersdorff G, Loos M, et al Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004; 113 : 1390–7. [Google Scholar]

[22] Kestila M, Lenkkeri U, Mannikko M, et al. Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1 : 575–82. [Google Scholar]

[23] Jones N, Blasutig IM, Eremina V, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006; 440 : 818–23. [Google Scholar]

[24] Verma R, Kovari I, Soofi A, et al. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 2006; 116 : 1346–59. [Google Scholar]

[25] Verma R, Wharram B, Kovari I, et al. Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 2003; 278 : 20716–23. [Google Scholar]

[26] Li H, Lemay S, Aoudjit L, et al. SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. J Am Soc Nephrol 2004; 15 : 3006–15. [Google Scholar]

[27] Quack I, Rump LC, Gerke P, et al. beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity. Proc Natl Acad Sci USA 2006; 103 : 14110–5. [Google Scholar]

[28] Huber TB, Hartleben B, Kim J, et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol 2003; 23 : 4917–28. [Google Scholar]

[29] Chen M, She H, Davis E, et al. Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. J Biol Chem 1998; 273 : 25171–8. [Google Scholar]

[30] Done SC, Takemoto M, He L, et al. Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int 2008; 73 : 697–704. [Google Scholar]