Free Access
Issue
Med Sci (Paris)
Volume 30, Number 2, Février 2014
Page(s) 160 - 165
Section M/S Revues
DOI https://doi.org/10.1051/medsci/20143002013
Published online 24 February 2014
  1. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013 ; 13 : 260–268. [CrossRef] [PubMed] [Google Scholar]
  2. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003 ; 348 : 138–150. [CrossRef] [PubMed] [Google Scholar]
  3. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013 ; 369 : 840–851. [CrossRef] [PubMed] [Google Scholar]
  4. Meakins JL, Pietsch JB, Bubenick O, et al. Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 1977 ; 186 : 241–250. [CrossRef] [PubMed] [Google Scholar]
  5. Monneret G, Venet F, Pachot A, Lepape A. Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 2008 ; 14 : 64–78. [CrossRef] [PubMed] [Google Scholar]
  6. Venet F, Lukaszewicz AC, Payen D, et al. Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies. Curr Opin Immunol 2013 ; 25 : 477–483. [CrossRef] [PubMed] [Google Scholar]
  7. Castelino DJ, McNair P, Kay TW. Lymphocytopenia in a hospital population-what does it signify? Aust NZ J Med 1997 ; 27 : 170–174. [CrossRef] [Google Scholar]
  8. Venet F, Davin F, Guignant C, et al. Early assessment of leukocyte alterations at diagnosis of septic shock. Shock 2010 ; 34 : 358–363. [CrossRef] [PubMed] [Google Scholar]
  9. Le Tulzo Y, Pangault C, Gacouin A, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002 ; 18 : 487–494. [CrossRef] [PubMed] [Google Scholar]
  10. Felmet KA, Hall MW, Clark RS, et al. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol 2005 ; 174 : 3765–3772. [PubMed] [Google Scholar]
  11. Inoue S, Suzuki-Utsunomiya K, Okada Y, et al. Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly. Crit Care Med 2013 ; 41 : 810–819. [CrossRef] [PubMed] [Google Scholar]
  12. Carson WF, Cavassani KA, Dou Y, Kunkel SL. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011 ; 6 : 273–283. [CrossRef] [PubMed] [Google Scholar]
  13. Van de Veerdonk FL, Mouktaroudi M, Ramakers BP, et al. Deficient Candida-specific T-helper 17 response during sepsis. J Infect Dis 2012 ; 206 : 1798–1802. [CrossRef] [PubMed] [Google Scholar]
  14. Zajac AJ, Blattman JN, Murali-Krishna K, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med ; 188 : 2205–2213. [CrossRef] [PubMed] [Google Scholar]
  15. Wherry EJ. T cell exhaustion. Nat Immunol 2011 ; 12 : 492–499. [CrossRef] [PubMed] [Google Scholar]
  16. Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, Green JM, A prospective analysis of lymphocyte phenotype, function over the course of acute sepsis. Crit Care 2012 ; 16 : R112. [CrossRef] [PubMed] [Google Scholar]
  17. Boomer JS, To K, Chang KC, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011 ; 306 : 2594–2605. [CrossRef] [PubMed] [Google Scholar]
  18. Guignant C, Lepape A, Huang X, et al. Programmed death-1 levels correlate with increased mortality, nosocomial infection, immune dysfunctions in septic shock patients. Crit Care 2011 ; 15 : R99. [CrossRef] [PubMed] [Google Scholar]
  19. Christou NV, Meakins JL, Gordon J, et al. The delayed hypersensitivity response and host resistance in surgical patients. 20 years later. Ann Surg 1995 ; 222 : 534–548. [CrossRef] [PubMed] [Google Scholar]
  20. Venet F, Bohe J, Debard AL, et al. Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shock. Crit Care Med 2005 ; 33 : 2836–2840. [CrossRef] [PubMed] [Google Scholar]
  21. Venet F, Filipe-Santos O, Lepape A, et al. Decreased T cell repertoire diversity in sepsis: a preliminary study. Crit Care Med 2013 ; 41 : 111–119. [CrossRef] [PubMed] [Google Scholar]
  22. Monneret G, Debard AL, Venet F, et al. Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003 ; 31 : 2068–2071. [CrossRef] [PubMed] [Google Scholar]
  23. Venet F, Chung CS, Kherouf H, et al. Increased circulating regulatory T cells (CD4+CD25+CD127-) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009 ; 35 : 678–686. [CrossRef] [PubMed] [Google Scholar]
  24. Hotchkiss RS, Opal S. Immunotherapy for sepsis-a new approach against an ancient foe. N Engl J Med 2010 ; 363 : 87–89. [CrossRef] [PubMed] [Google Scholar]
  25. Docke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997 ; 3 : 678–681. [CrossRef] [PubMed] [Google Scholar]
  26. Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009 ; 180 : 640–648. [CrossRef] [PubMed] [Google Scholar]
  27. Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011 ; 11 : 330–342. [CrossRef] [PubMed] [Google Scholar]
  28. Lundstrom W, Fewkes NM, Mackall CL. IL-7 in human health and disease. Semin Immunol 2012 ; 24 : 218–224. [CrossRef] [PubMed] [Google Scholar]
  29. Morre M, Beq S. Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival. Target Oncol 2012 ; 7 : 55–68. [CrossRef] [PubMed] [Google Scholar]
  30. Unsinger J, Burnham CA, McDonough J, et al. Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis 2012 ; 206 : 606–616. [CrossRef] [PubMed] [Google Scholar]
  31. Unsinger J MM, Kasten KR, Hoekzema AS, et al. IL-7 Promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol 2010 ; 184 : 3768–3779. [CrossRef] [PubMed] [Google Scholar]
  32. Venet F, Foray AP, Villars-Mechin A, et al. IL-7 restores lymphocyte functions in septic patients. J Immunol 2012 ; 189 : 5073–5081. [CrossRef] [PubMed] [Google Scholar]
  33. Kasten KR, Prakash PS, Unsinger J, et al. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun 2010 ; 78 : 4714–4722. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.