EDP Sciences logo
Subscriber Authentication Point
Search
Menu
Home All issues Volume 18 / No 1 (Janvier 2002) Med Sci (Paris), 18 1 (2002) 70-78 References
Free Access
Issue
Med Sci (Paris)
Volume 18, Number 1, Janvier 2002
Page(s) 70 - 78
Section M/S Revues : Articles de Synthèse
DOI https://doi.org/10.1051/medsci/200218170
Published online 15 January 2002
  1. Goldberg MA, Schneider TJ. Similarities between the oxygen -sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 1994; 269:4355–9. [Google Scholar]
  2. Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of Hypoxiainducible factor 1. J Biol Chem 1996; 271 : 17771–8. [Google Scholar]
  3. Guillemin K, Krasnow MA. The hypoxic response: huffing and HIFing. Cell 1997; 89 : 9–12. [Google Scholar]
  4. Semenza GL. Hypoxiainducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998; 8: 588–94. [Google Scholar]
  5. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxiainducible nuclear factors bind to an enhancer element located 3’ to the human erythro-poietin gene. Proc Natl Acad Sci USA 1991; 88 : 5680–4. [Google Scholar]
  6. Wang GL, Jiang BH, Rue EA, Semenza G. L. Hypoxiainducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92 : 5510–4. [Google Scholar]
  7. Wang GL, Semenza GL. Purification and characterization of Hypoxiainducible factor 1. J Biol Chem 1995; 270 : 1230–7. [Google Scholar]
  8. Wenger RH, Rolfs A, Kvietikova I, Spielmann P, Zimmermann, DR, Gassmann M. The mouse gene for Hypoxiainducible factor-1alpha-genomic organization, expression and characterization of an alternative first exon and 5’ flanking sequence. Eur J Biochem 1997; 246 : 155–65. [Google Scholar]
  9. Luo G, Gu YZ, Jain S, Chan WK, Carr KM, Hogenesch JB, Bradfield CA. Molecular characterization of the murine HIf-1 alpha locus. Gene Expr 1997; 6 : 287–99. [Google Scholar]
  10. Gothie E, Richard DE, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J Biol Chem 2000; 275 : 6922–7. [Google Scholar]
  11. Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxiainducible factor 1. Biochem Biophys Res Commun 1996; 225 : 485–8. [Google Scholar]
  12. Wenger RH, Rolfs A, Marti HH, Guenet JL, Gassmann M. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun 1996 223 : 54–9. [Google Scholar]
  13. Hirose K, Morita M, Ema M, et al. cDNA cloning and tissuespecific expression of a novel basic helixloop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 1996; 16 : 1706–13. [Google Scholar]
  14. Drutel G, Kathmann M, Heron A, Schwartz JC, Arrang JM. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT). Biochem Biophys Res Commun 1996; 225 : 333–9. [Google Scholar]
  15. Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza G.L. Transactivation and inhibitory domains of hypoxiainducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem 1997; 272 : 19253–60. [Google Scholar]
  16. Pugh CW, O’Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997; 272 : 11205–14. [Google Scholar]
  17. O’Rourke JF, Tian YM, Ratcliffe PJ, Pugh CW. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxiainducible factor-1alpha. J Biol Chem 1999; 274 : 2060–71. [Google Scholar]
  18. Salceda S, Caro J. hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997; 272 : 22642–7. [Google Scholar]
  19. Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitinproteasome pathway. Proc Natl Acad Sci USA 1998; 95 : 7987–92. [Google Scholar]
  20. Srinivas V, Zhang LP, Zhu XH, Caro J. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins. Biochem Biophys Res Commun 1999; 260 : 557–61. [Google Scholar]
  21. Kallio PJ, Okamoto K, O’Brien S, et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxiainducible factor-1alpha. EMBO J 1998; 17 : 6573–86. [Google Scholar]
  22. Jaakkola P, Mole DR, Tian Y, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated Prolyl hydroxylation. Science 2001; 292 : 468–72. [Google Scholar]
  23. Ivan M, Kondo K, Yang H, et al. HIF alpha targeted for VHL- mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 2001; 292 : 464–8. [Google Scholar]
  24. Gradin K, McGuire J, Wenger RH, et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996; 16 : 5221–31. [Google Scholar]
  25. Kallio PJ, Wilson WJ, O’Brien S, Makino Y, Poellinger L. Regulation of the hypoxiainducible transcription factor 1aipha by the ubiquitin-pro-teasome pathway. J Biol Chem 1999; 274 : 6519–25. [Google Scholar]
  26. Sutter CH, Laughner E, Semenza GL. Hypoxiainducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000; 97 : 4748–53. [Google Scholar]
  27. Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxiainducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000; 19 : 4298–309. [Google Scholar]
  28. Cockman ME, Masson N, Mole DR, et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000; 275 : 25733–41. [Google Scholar]
  29. Ohh M, Park CW, Ivan M, et al, Ubiquitination of hypoxiainducible factor requires direct binding to the betadomain of the von Hippel-Lindau protein. Nat Cell Biol 2000; 2 : 423–7. [Google Scholar]
  30. Berra E, Richard DE, Gothie E, Pouyssegur J. HIF-1-dependent transcriptional activity is required for oxygenmediated HIF-1alpha degradation. FEBS Lett 2001; 491 : 85–90. [Google Scholar]
  31. Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 2000; 14 : 34–44. [Google Scholar]
  32. Pollenz RS, Sattler CA, Poland A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1e1c7 cells by immunofluorescence microscopy. Mol Pharmacol 1994; 45 : 428–38. [Google Scholar]
  33. Eguchi H, Ikuta T, Tachibana T, Yoneda Y, Kawajiri K. A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1beta is a novel bipartite type recognized by the two components of nuclear poretargeting complex. J Biol Chem 1997; 272 : 17640–7. [Google Scholar]
  34. Carrero P, Okamoto K, Coumailleau P, O’Brien S, Tanaka H, Poellinger L. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol 2000; 20 : 402–15. [Google Scholar]
  35. Minet E, Mottet D, Michel G, et al. Hypoxia-induced activation of HIF-1: role of HIF-1aipha-Hsp90 interaction. FEBS Lett 1999; 460 : 251–6. [Google Scholar]
  36. Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L. Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Hatl Acad Sci USA 1997; 94 : 5667–72. [Google Scholar]
  37. Galson DL, Tsuchiya T, Tendler DS, et al. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 1995; 15 : 2135–44. [Google Scholar]
  38. Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000; 275 : 26765–71. [Google Scholar]
  39. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 1998; 17 : 5085–94. [Google Scholar]
  40. Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. p42/p44 mitogenactivated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1aipha) and enhance the transcriptional activity of HIF-l. J Biot Chem 1999; 274 : 32631–7. [Google Scholar]
  41. Semenza GL. hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2002 (sous presse). [Google Scholar]
  42. Bianchi L, Tacchini L, Cairo G. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Acids Res 1999; 27 : 4223–7. [Google Scholar]
  43. Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angio-genesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997; 386 : 403–7. [Google Scholar]
  44. lyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998; 12:149–62. [Google Scholar]
  45. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394 : 485–90. [Google Scholar]
  46. Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17 : 3005–15. [Google Scholar]
  47. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435–9. [Google Scholar]
  48. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380 : 439–42. [Google Scholar]
  49. Maxwell PH, Dachs GU, Gleadle JM, et al. hypoxia-inducible factor-1 modulâtes gerne expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 1997; 94 : 8104–9. [Google Scholar]
  50. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci USA 1999 96; 14742–7. [Google Scholar]
  51. Semenza GL. Perspectives on oxygen sensing. Cell 1999; 98 : 281–4. [Google Scholar]
  52. Wood SM, Wiesener MS, Yeates KM, et al. Selection and analysis of a mutant cell line defective in the hypoxiainducible factor-1 alphasubunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxiainducible gene expression. J Biol Chem 1998; 273 : 8360–8. [Google Scholar]
  53. Ruan H, Wang J, Hu L, Lin CS, Lamborn KR, Deen DF. Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX. Neoplasia 1999; 1 : 431–7. [Google Scholar]
  54. Li J, Post M, Volk R, et al. PR39, a peptide regulator of angiogenesis. Nat Med 2000; 6 : 49–55. [Google Scholar]
  55. Berra E, Roux D, Richard DE, Pouysségur J. hypoxia-inducible factor -1alpha (HIF-1alpha) escapes O2-driven proteosomal degradation irrespectively of its subcellular localization. EMBO Rep 2001; 2 : 615–20. [Google Scholar]
  56. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107 : 43–54. [Google Scholar]
  57. Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294 : 1337–40. [Google Scholar]
  58. Brahimi-Horn C, Berra E, Pouysségur J. Hypoxia: the tumor’s gateway to progression along the angiogenic pathway. Trends Cell Biol 2001; 11 : S32–6. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.