Free Access
Med Sci (Paris)
Volume 18, Number 1, Janvier 2002
Page(s) 79 - 85
Section M/S Revues : Mini-Synthéses
Published online 15 January 2002
  1. Werner O. On cataract in conjunction with scleroderma (translated by H. Hoehn). In : Salk D, Fujiwara Y, Martin GM eds. Werner’s syndrome and human aging,1st ed New York : Plenum Press,1985 : 1–14 [Google Scholar]
  2. Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner’s syndrome: A review of its symptomatology, natural his-tory, pathologic features, genetics and relationship to the natural aging process. Medicine 1966; 45 : 177–221. [Google Scholar]
  3. Goto M. Werner’s syndrome: From clinics to genetics. Clin Exp Rheumatoi 2000; 18 : 760–6. [Google Scholar]
  4. Goto M, Miller RW, Ishikawa Y, Sugano H. Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev 1996; 5 : 239–46. [Google Scholar]
  5. Monnat RJ Jr. Cancer patho-genesis in the human RecQ helicase deficiency syndromes. In : Goto M., Miller RW eds. From premature gray hair to helicase: Werner syndrome implications for aging and cancer. Gann Monograph on Cancer Research 2001; 49:83–94. [Google Scholar]
  6. Yu CE, Oshima J, Fu YH, et ai Positional cloning of the Werner’s syndrome gene. Science 1996; 272 : 258–62. [Google Scholar]
  7. Chakraverty RK, Hickson ID. Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. BioEssays 1999; 21 : 286–94. [Google Scholar]
  8. van Brabant AJ, Stan R, Ellis NA. DNA helicases, genomic instability, and human gene-tic disease. Annu Rev Genêt 2000; 1 : 409–59. [Google Scholar]
  9. Shen JC, Loeb LA. Unwinding the molecular basis of the Werner syndrome. Mech Ageing Dev 2001; 122 : 921–44. [Google Scholar]
  10. Moser MJ, Oshima J, Monnat RJ Jr. WRN mutations in Werner syndrome. Hum Mutât 13: 271–9 [Google Scholar]
  11. Goto M, Yamabe Y, Shiratori M, et ai Immunological dia-gnosis of Werner syndrome by down-regulated and truncated gene products. Hum Genêt 1999; 105 : 301–7. [Google Scholar]
  12. Moser MJ, Kamath-Loeb AS, Jacob JE, Bennett SE, Oshima J, Monnat RJ Jr. WRN helicase expression in Werner syndrome cell lines. Nucleic Acids Res 2000; 28 : 648–54. [Google Scholar]
  13. Mohaghegh P, Hickson ID. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum Mol Genet 2001; 10: 741–6. [Google Scholar]
  14. Shen JC, Loeb LA. The Werner syndrome gene: the molecular basis of RecQ helicasedeficiency diseases. Trends Genet 2000; 16 : 213–20. [Google Scholar]
  15. Fukuchi K, Martin GM, Monnat RJ Jr. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 1989; 86 : 5893–7. [Google Scholar]
  16. Prince PR, Emond MJ, Monnat RJ Jr. Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev 2001;15 : 933–8. [Google Scholar]
  17. Thompson LH, Schild D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat Res 2001; 477 : 131–53. [Google Scholar]
  18. Constantinou A, Davies AA, West SC. Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells. Cell 2001; 104 : 259–68. [Google Scholar]
  19. ye L, Miki T, Nakura J, et al. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Hum Genet 1997; 68 : 494–8. [Google Scholar]
  20. Castro E, Ogburn CE, Hunt KE, et al. Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. Am J Med Genet 1999; 82 : 399–403. [Google Scholar]
  21. Castro E, Edland SD, Lee L, et al. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Am J Med Genet 2000; 95 : 374–80. [Google Scholar]
  22. Moser MJ, Bigbee WL, Grant SG, et al. Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes. Cancer Res 2000; 60 : 2492–6. [Google Scholar]
  23. Jensen RH, Bigbee WL. Direct immunofluorescence labelling provides an improved method for the glycophorin A somatic mutation assay. Cytometry 1996; 23 : 337–43. [Google Scholar]
  24. Poot M, Gollahon KA, Rabinovitch PS. Werner syndrome lymphoblastoid cells are sensitivie to camptothecin-induced apoptosis in S-phase. Hum Genet 1999; 104: 10–4. [Google Scholar]
  25. Goto M, Tanimoto K, Horiuchi Y, Sasazuki T. Family analysis of Werner’s syndrome: a survey of 42 Japanese families with a review of the literature. Clin Genet 1981; 19 : 8–15. [Google Scholar]
  26. Cerimele D, Cottoni F, Scappaticci SG, et al. 1982. High prevalence of Werner’s syndrome in Sardinia: description of six patients and estimate of the gene frequency. Hum Genet 1982; 62 : 25–30. [Google Scholar]
  27. Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS. Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J 2001; 15 : 1224–6. [Google Scholar]
  28. Matsumura T, Nagata M, Konishi R, Goto M. Studies of SV40-infected Werner syndrome fibroblasts. Adv Exp Med Biol 1985; 190 : 313–30. [Google Scholar]
  29. Prince PR, Ogburn CE, Moser MJ, Emond MJ, Martin GM, Monnat RJ Jr. Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines. Hum Genet 1999; 105 : 132–8. [Google Scholar]
  30. Fry M, Loeb LA. The three faces of the WS helicase. Nat Genet 1998; 19 : 308–9. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.