Open Access
Tableau II
Effets indésirables des CAR-T (d’aprés [46]).
| Risque | Exemples d’approche |
|---|---|
| On target/off tumor (Sur la cible mais hors tumeur) | Identification de cibles spécifiques Expression conditionnelle du CAR |
| Génotoxicité | Utilisation de vecteurs lentiviraux |
| Relargage cytokinique (Cytokine Release Syndrome) | Diminution de la dose Injection locorégionale |
| Syndrome de neurotoxicité (Immune effector Cell-Associated Neurotoxicity Syndrome) | Diminution de la dose Injection locorégionale |
| Syndrome de lyse tumorale (Tumor Lysis Syndrome) Anaphylaxie | Gène suicide ou mimotope |
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