Figure 3.
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Schéma d’un lentivirus CAR-T CD19. (selon BPS Bioscience, https://bpsbioscience.com/anti-cd19-car-lentivirus-cd19-scfv-cd8-4-1bb-cd3z-78600). LTR : long terminal repeat ; RRE : Rev-responsive element ; cPPT/CTS : central polypurine tract/central termination sequence ; IRES : IUnternal ribosome entry site ; PuroR : gène de résistance à la puromycine ; WPRE : Woodchuckhepatitis hirus posttranscriptional regulatory element ; 3’-UTR : 3’Untranslated region ; AmpR : gène de résistance à l’ampicilline ; VL et FL : chaînes légère et lourde des immunoglobulines, respectivement.
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