Open Access
Tableau I.
ADC approuvés ou en phases cliniques avancées (III ou II pivotale).
| ADC (cytotoxique) | Isotype et Cible | Indication, date d’approbation/Statut Ph clinique |
|---|---|---|
| gemtuzumab ozogamicine (CAL) | IgG4 CD33 | 2000-2010/2017 AML |
| brentuximab védotine (AUR) | IgG1 CD30 | 2011 ALCL et lymphoma de Hodgkin |
| trastuzumab emtansine (MAY) | IgG1 HER2+ | 2013 cancer du sein métastatique HER2+++ |
| inotuzumab ozogamicine (CAL) | IgG4 CD22 | 2017 ALL and CLL |
| polatuzumab védotine (AUR) | IgG1 CD79b | 2019 DLBCL |
| sacituzumab govitécan (IRI)* | IgG1 TROP-2 | BLA, TNBC métastatique |
| enfortumab védotine (AUR)* | IgG1 Nectine 4 | BLA, Piv. Ph 2 cancer urothéliale |
| trastuzumab déruxtécan (EXA)* | IgG1 HER2/neu+ | Ph 3 cancer du sein HER2+++ vs T-DM1 |
| trastuzumab duocarmazine (DUO)* | IgG1 HER2/neu+ | Ph 3 cancer du sein HER2+++ vs T-DM1 |
| mirvetuximab soravtansine (MAY)* | IgG1 Folate R1 | Ph 3 cancer de l’ovaire épithélial |
| belantamab mafodotine (AUR) | IgG1afuc BCMA | Piv. Ph2 myélome multiple |
| loncastuximab tésirine (PBD) | IgG1 CD19 | Piv. Ph2 DLBCL |
| depatuxizumab mafodotine (AUR) | IgG1 EGFRvIII | Ph 3 glioblastome (étude stoppée) |
| rovalpituzumab tésirine (PBD) | IgG1 DLL3 | Ph 3 cancer du poumon à petites cellules (étude stoppée) |
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