Free Access
Tableau I.
Modèles poissons zèbres de dystrophies musculaires congénitales. DG : dystroglycane.
| Gène poisson zèbre | Type de modèle | Maladie humaine phénocopiée | Référence |
|---|---|---|---|
| Lame basale | |||
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| col6a1, col6a3 | Morphant | Dystrophie congénitale musculaire d’Ullrich et myopathie de Bethlem | [21] |
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| col22a1 | Morphant | Types multiples | [32] |
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| lama2 | Mutant (candyfloss) | Dystrophie musculaire congénitale (MDC1A) | [23, 28] |
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| lamb2 | Mutant (softy) | Types multiples | [27] |
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| Complexe d’adhésion | |||
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| cav3 | Morphant | Cavéolinopathie | [22] |
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| dag1 | Morphant | Dystrophie musculaire des ceintures de type 2P | [8] |
| Mutant (patchytail) | [32] | ||
| Mutant | [41] | ||
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| dmd | Morphant | Dystrophie musculaire de Duchenne | [19] |
| Mutant (sapje) | [37, 38] | ||
| Mutant (sapje-like) | [27] | ||
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| ilk | Mutant (loss contact) | Types multiples | [34] |
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| itg7 | Morphant | Dystrophie musculaire congénitale | [27] |
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| sgcd | Morphant | Dystrophie musculaire des ceintures de type 2F | [22] |
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| Glycosylation d’alpha-DG | |||
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| b3galnt2 | Morphant | Dystroglycanopathie | [43] |
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| b3gnt1 | Morphant | Syndrome de Walker-Warburg | [44] |
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| fkrp | Morphant | Dystroglycanopathie | [41] |
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| fktn | Morphant | Dystroglycanopathie | [41] |
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| gmppb | Morphant | Types multiples | [34, 45] |
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| gtdc2 | Morphant | Syndrome de Walker-Warburg | [46] |
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| ispd | Morphant | Syndrome de Walker-Warburg | [47] |
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| pomk | Morphant | Dystroglycanopathie | [48] |
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| pomt1, pomt2 | Morphant | Dystrophie musculaire des ceintures de type 2P et 2N | [49] |
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| Autres | |||
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| apo2a, apo2b | Morphant | Types multiples | [27] |
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| dnajb6b | Morphant | Dystrophie musculaire des ceintures de type 1E | [27] |
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| dux4 | Surexpression | Dystrophie facio-scapulo-humérale | [27] |
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| mstn2 | Surexpression | Types multiples | [27] |
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| sepn1 | Morphant | Types multiples | [27] |
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| tcap | Morphant | Dystrophie musculaire des ceintures de type 2G | [27] |
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| ttn | Mutant (runzel) | Types multiples | [50] |
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| tsp4b | Morphant | Types multiples | [27] |
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