Open Access
Issue
Med Sci (Paris)
Volume 37, Number 8-9, Août–Septembre 2021
Page(s) 712 - 715
Section Le Magazine
DOI https://doi.org/10.1051/medsci/2021099
Published online 07 September 2021
  1. Carelli V Carbonelli M de Coo IF et al. International consensus statement on the clinical and therapeutic management of Leber hereditary optic neuropathy. J Neuroophthalmol 2017 ; 37 : 371–381. [PubMed] [Google Scholar]
  2. Newman NJ, Carelli V, Taiel M, Yu-Wai-Man P. Visual outcomes in Leber hereditary optic neuropathy patients with the m.11778G>A (MTND4) mitochondrial DNA mutation. J Neuroophthalmol 2020; 40 : 547–57. [PubMed] [Google Scholar]
  3. Catarino CB, von Livonius B, Priglinger C, et al. Real-world clinical experience with Idebenone in the treatment of Leber hereditary optic neuropathy. J Neuroophthalmol 2020; 40 : 558–65. [PubMed] [Google Scholar]
  4. Cwerman-Thibault H Augustin S Lechauve C et al. Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss. Mol Ther Methods Clin Dev 2015 ; 2 : 15003. [PubMed] [Google Scholar]
  5. Vignal C Uretsky S Fitoussi S et al. Safety of rAAV2/2-ND4 gene therapy for Leber hereditary optic neuropathy. Ophthalmology 2018 ; 125 : 945–947. [PubMed] [Google Scholar]
  6. Vignal-Clermont C, Girmens JF, Audo I, et al. Safety of intravitreal gene therapy for treatment of subjects with Leber hereditary optic neuropathy due to mutations in the mitochondrial ND4 gene: the Reveal study. BioDrugs 2021; 35 : 201–14. [PubMed] [Google Scholar]
  7. Yu-Wai-Man P, Newman NJ, Carelli V, et al. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy. Sci Transl Med 2020; 12 : eaaz7423. [CrossRef] [PubMed] [Google Scholar]
  8. Newman NJ, Yu-Wai-Man P, Carelli V, el al. Efficacy and safety of intravitreal gene therapy for Leber hereditary optic neuropathy treated within 6 months of disease onset. Ophthalmology 2021; S0161–6420 : 31187–8. [PubMed] [Google Scholar]
  9. Yu-Wai-Man P, Newman NJ, Carelli V, et al. Natural history of patients with Leber hereditary optic neuropathy: results from the Reality study. Eye 2021; doi: 10.1038/s41433-021-01535-9. [Google Scholar]
  10. Newman NJ, Yu-Wai-Man P, Carelli V. Intravitreal gene therapy versus natural history in patients with Leber hereditary optic neuropathy carrying the m.11778G>A ND4 mutation: systematic review and indirect comparison. Front Neurosci 2021; doi: 10.3389/fneur.2021.662838. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.