EDP Sciences logo
Subscriber Authentication Point
Search
Menu
Home All issues Volume 33 / No 4 (Avril 2017) Med Sci (Paris), 33 4 (2017) 432-439 References
Free Access
Issue
Med Sci (Paris)
Volume 33, Number 4, Avril 2017
Page(s) 432 - 439
Section M/S Revues
DOI https://doi.org/10.1051/medsci/20173304014
Published online 12 May 2017
  1. Kinoshita T. Biosynthesis and deficiencies of glycosylphosphatidylinositol. Proc Jpn Acad Ser B Phys Biol Sci 2014 ; 90 : 130–143. [CrossRef] [PubMed] [Google Scholar]
  2. Kawagoe K, Takeda J, Endo Y, et al. Molecular cloning of murine Pig-a, a gene for GPI-anchor biosynthesis, and demonstration of interspecies conservation of its structure, function, and genetic locus. Genomics 1994 ; 23 : 566–574. [CrossRef] [PubMed] [Google Scholar]
  3. Peruzzi B, Araten DJ, Notaro R, et al. The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo. Mutat Res 2010 ; 705 : 3–10. [CrossRef] [PubMed] [Google Scholar]
  4. Araten DJ, Nafa K, Pakdeesuwan K, et al. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Proc Natl Acad Sci USA 1999 ; 96 : 5209–5214. [CrossRef] [Google Scholar]
  5. Takeda J, Miyata T, Kawagoe K, et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 1993 ; 73 : 703–711. [CrossRef] [PubMed] [Google Scholar]
  6. Augui S, Heard E. Inactivation du chromosome X. Med Sci (Paris) 2008 ; 24 : 584–585. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  7. Vallot C, Rougeulle C Inactivation du chromosome X chez l’humain. Med Sci (Paris) 2013 ; 29 : 223–225. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  8. Rosse WF Dr Ham’s test revisited (editorial). Blood 1991 ; 78 : 547–550. [Google Scholar]
  9. Brodsky RA Paroxysmal nocturnal hemoglobinuria. Blood 2014 ; 124 : 2804–2811. [Google Scholar]
  10. Clive D, Flamm WG, Machesko MR, et al. A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat Res 1972 ; 16 : 77–87. [CrossRef] [PubMed] [Google Scholar]
  11. Gollapudi BB, Lynch AM, Heflich RH, et al. The in vivo Pig-a assay: a report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup. Mutat Res 2015 ; 783 : 23–35. [CrossRef] [PubMed] [Google Scholar]
  12. Kimoto T, Suzuki K, Kobayashi X mei, et al. Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression. Mutat Res 2011 ; 723 : 36–42. [CrossRef] [PubMed] [Google Scholar]
  13. Dobrovolsky VN, Revollo J, Pearce MG, et al. CD48-deficient T-lymphocytes from DMBA-treated rats have de novo mutations in the endogenous Pig-a gene. Environ Mol Mutagen 2015 ; 56 : 674–683. [CrossRef] [PubMed] [Google Scholar]
  14. Miura D, Dobrovolsky VN, Mittelstaedt RA, et al. Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants. Environ Mol Mutagen 2008 ; 49 : 622–630. [CrossRef] [PubMed] [Google Scholar]
  15. Hu R, Mukhina GL, Piantadosi S, et al. PIG-A mutations in normal hematopoiesis. Blood 2005 ; 105 : 3848–3854. [Google Scholar]
  16. Albertini RJ, Nicklas JA, O’Neill JP, et al. In vivo somatic mutations in humans: measurement and analysis. Annu Rev Genet 1990 ; 24 : 305–326. [CrossRef] [PubMed] [Google Scholar]
  17. Borowitz MJ, Craig FE, DiGiuseppe JA, et al. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry 2010 ; 78B : 211–230. [Google Scholar]
  18. Parker C. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 2005 ; 106 : 3699–3709. [Google Scholar]
  19. Sutherland DR, Keeney M, Illingworth A. Practical guidelines for the high-sensitivity detection and monitoring of paroxysmal nocturnal hemoglobinuria clones by flow cytometry. Cytometry 2012 ; 82B : 195–208. [Google Scholar]
  20. Phonethepswath S, Bryce SM, Bemis JC, et al. Erythrocyte-based Pig-A gene mutation assay: Demonstration of cross-species potential. Mutat Res 2008 ; 657 : 122–126. [CrossRef] [PubMed] [Google Scholar]
  21. Miura D, Dobrovolsky VN, Kimoto T, et al. Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea. Mutat Res 2009 ; 677 : 86–92. [CrossRef] [PubMed] [Google Scholar]
  22. Ware RE, Rosse WF, Hall SE Immunophenotypic analysis of reticulocytes in paroxysmal nocturnal hemoglobinuria. Blood 1995 ; 86 : 1586–1589. [Google Scholar]
  23. Dertinger SD, Avlasevich SL, Bemis JC, et al. Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples. Environ Mol Mutagen 2015 ; 56 : 366–377. [CrossRef] [PubMed] [Google Scholar]
  24. Wickrema A, Crispino JD Erythroid and megakaryocytic transformation. Oncogene 2007 ; 26 : 6803–6815. [Google Scholar]
  25. Phonethepswath S, Franklin D, Torous DK, et al. Pig-A mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens. Toxicol Sci 2010 ; 114 : 59–70. [CrossRef] [PubMed] [Google Scholar]
  26. Dertinger SD, Phonethepswath S, Franklin D, et al. Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies. Toxicol Sci 2010 ; 115 : 401–411. [CrossRef] [PubMed] [Google Scholar]
  27. Dertinger SD, Bryce SM, Phonethepswath S, et al. When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis. Mutat Res 2011 ; 721 : 163–170. [CrossRef] [PubMed] [Google Scholar]
  28. Kimoto T, Chikura S, Suzuki K, et al. Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ Mol Mutagen 2011 ; 52 : 774–783. [CrossRef] [PubMed] [Google Scholar]
  29. Ohtani S, Unno A, Ushiyama A, et al. The in vivo Pig-a gene mutation assay is useful for evaluating the genotoxicity of ionizing radiation in mice. Environ Mol Mutagen 2012 ; 53 : 579–588. [CrossRef] [PubMed] [Google Scholar]
  30. Kimoto T, Horibata K, Chikura S, et al. Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat Res 2013 ; 755 : 126–134. [CrossRef] [PubMed] [Google Scholar]
  31. Dertinger SD, Phonethepswath S, Avlasevich SL, et al. Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone. Environ Mol Mutagen 2014 ; 55 : 299–308. [CrossRef] [PubMed] [Google Scholar]
  32. Itoh S, Hattori C, Nakayama S, et al. PIGRET assay can detect mutagenicity of ethyl methanesulfonate much earlier than RBC Pig-a assay. Mutat Res 2016 ; 811 : 102–105. [CrossRef] [PubMed] [Google Scholar]
  33. Dertinger SD, Phonethepswath S, Avlasevich SL, et al. Efficient monitoring of in vivo Pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds. Toxicol Sci 2012 ; 130 : 328–348. [CrossRef] [PubMed] [Google Scholar]
  34. Luzzatto L, Bessler M, Rotoli B Somatic mutations in paroxysmal nocturnal hemoglobinuria: a blessing in disguise? Cell 1997 ; 88 : 1–4. [CrossRef] [PubMed] [Google Scholar]
  35. Labash C, Avlasevich SL, Carlson K, et al. Comparison of male versus female responses in the Pig-a mutation assay. Mutagenesis 2015 ; 30 : 349–357. [CrossRef] [PubMed] [Google Scholar]
  36. Rondelli T, Berardi M, Peruzzi B, et al. The frequency of granulocytes with spontaneous somatic mutations: a wide distribution in a normal human population. PLoS One 2013 ; 8 : e54046. [CrossRef] [PubMed] [Google Scholar]
  37. Kenyon MO, Coffing SL, Ackerman JI, et al. Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol. Mutagenesis 2015 ; 30 : 325–334. [CrossRef] [PubMed] [Google Scholar]
  38. Krüger CT, Hofmann M, Hartwig A The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells. Arch Toxicol 2014 : 2429–2443. [PubMed] [Google Scholar]
  39. Chen R, Eshleman JR, Brodsky RA, et al. Glycophosphatidylinositol-anchored protein deficiency as a marker of mutator phenotypes in cancer. Cancer Res 2001 ; 61 : 654–658. [Google Scholar]
  40. Dobrovolsky VN, Elespuru RK, Bigger CAH, et al. Monitoring humans for somatic mutation in the endogenous pig-a gene using red blood cells. Environ Mol Mutagen 2011 ; 52 : 784–794. [CrossRef] [PubMed] [Google Scholar]
  41. Bhalli JA, Shaddock JG, Pearce MG, et al. Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens. Mutagenesis 2013 ; 28 : 447–455. [CrossRef] [PubMed] [Google Scholar]
  42. Labash C, Avlasevich SL, Carlson K, et al. Mouse Pig-a and micronucleus assays respond to N-ethyl- N -nitrosourea, benzo[a ]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate: Cross-species Pig-a and micronucleated reticulocyte assays. Environ Mol Mutagen 2016 ; 57 : 28–40. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.