Free Access
Issue
Med Sci (Paris)
Volume 29, Number 3, Mars 2013
Page(s) 301 - 307
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2013293017
Published online 27 March 2013
  1. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010 ; 40 : 179–204. [CrossRef] [PubMed] [Google Scholar]
  2. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature 2012 ; 481 : 287–294. [CrossRef] [PubMed] [Google Scholar]
  3. Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010 ; 11 : 196–207. [CrossRef] [PubMed] [Google Scholar]
  4. San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Ann Rev Biochem 2008 ; 77 : 229–257. [CrossRef] [Google Scholar]
  5. Krejci L, Altmannova V, Spirek M, Zhao X. Homologous recombination and its regulation. Nucleic Acids Res 2012 ; 40 : 5795–5818. [CrossRef] [PubMed] [Google Scholar]
  6. West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003 ; 4 : 435–445. [CrossRef] [PubMed] [Google Scholar]
  7. Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer 2012 ; 12 : 68–78. [CrossRef] [Google Scholar]
  8. Yang H, Jeffrey PD, Miller J, et al. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 2002 ; 297 : 1837–1848. [CrossRef] [PubMed] [Google Scholar]
  9. Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol 2010 ; 17 : 1260–1262. [CrossRef] [PubMed] [Google Scholar]
  10. Davies AA, Masson JY, McIlwraith MJ, et al. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell 2001 ; 7 : 273–282. [CrossRef] [PubMed] [Google Scholar]
  11. Carreira A, Kowalczykowski SC. Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms. Proc Natl Acad Sci USA 2011 ; 108 : 10448–10453. [CrossRef] [Google Scholar]
  12. Chen CF, Chen PL, Zhong Q, et al. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J Biol Chem 1999 ; 274 : 32931–32935. [CrossRef] [PubMed] [Google Scholar]
  13. Galkin VE, Esashi F, Yu X, et al. BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci USA 2005 ; 102 : 8537–8542. [CrossRef] [Google Scholar]
  14. Saeki H, Siaud N, Christ N, et al. Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc Natl Acad Sci USA 2006 ; 103 : 8768–8773. [CrossRef] [Google Scholar]
  15. Esashi F, Christ N, Gannon J, et al. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005 ; 434 : 598–604. [CrossRef] [PubMed] [Google Scholar]
  16. Esashi F, Galkin VE, Yu X, et al. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol 2007 ; 14 : 468–474. [CrossRef] [PubMed] [Google Scholar]
  17. Davies OR, Pellegrini L. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat Struct Mol Biol 2007 ; 14 : 475–483. [PubMed] [Google Scholar]
  18. Schlacher K, Christ N, Siaud N, et al. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 2011 ; 145 : 529–542. [CrossRef] [PubMed] [Google Scholar]
  19. Ayoub N, Rajendra E, Su X, et al. The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol 2009 ; 19 : 1075–1085. [CrossRef] [PubMed] [Google Scholar]
  20. Xia B, Sheng Q, Nakanishi K, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 2006 ; 22 : 719–729. [CrossRef] [PubMed] [Google Scholar]
  21. Tischkowitz M, Xia B. PALB2/FANCN: recombining cancer and Fanconi anemia. Cancer Res 2010 ; 70 : 7353–7359. [CrossRef] [PubMed] [Google Scholar]
  22. Zhang F, Ma J, Wu J, et al. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 2009 ; 19 : 524–529. [CrossRef] [PubMed] [Google Scholar]
  23. Buisson R, Masson JY. PALB2 self-interaction controls homologous recombination. Nucleic Acids Res 2012 ; 40 : 10312–10323. [CrossRef] [PubMed] [Google Scholar]
  24. Bleuyard JY, Buisson R, Masson JY, Esashi F. ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. EMBO Rep 2012 ; 13 : 135–141. [CrossRef] [PubMed] [Google Scholar]
  25. Buisson R, Dion-Cote AM, Coulombe Y, et al. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol 2010 ; 17 : 1247–1254. [CrossRef] [PubMed] [Google Scholar]
  26. Dray E, Etchin J, Wiese C, et al. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol 2010 ; 17 : 1255–1259. [CrossRef] [PubMed] [Google Scholar]
  27. Jensen RB, Carreira A, Kowalczykowski SC. Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 2010 ; 467 : 678–683. [CrossRef] [PubMed] [Google Scholar]
  28. Thorslund T, McIlwraith MJ, Compton SA, et al. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol 2010 ; 17 : 1263–1265. [CrossRef] [PubMed] [Google Scholar]
  29. Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007 ; 316 : 1160–1166. [CrossRef] [PubMed] [Google Scholar]
  30. Bunting SF, Callen E, Wong N, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010 ; 141 : 243–254. [CrossRef] [PubMed] [Google Scholar]
  31. Miné-Hattab J, Rothstein R. Réparation de l’ADN : comment trouver le bon partenaire ? Med sci (Paris) 2012 ; 28 : 714–716. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.