Accès gratuit
Numéro
Med Sci (Paris)
Volume 29, Numéro 3, Mars 2013
Page(s) 301 - 307
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2013293017
Publié en ligne 27 mars 2013
  1. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010 ; 40 : 179–204. [CrossRef] [PubMed]
  2. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature 2012 ; 481 : 287–294. [CrossRef] [PubMed]
  3. Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010 ; 11 : 196–207. [CrossRef] [PubMed]
  4. San Filippo J, Sung P, Klein H. Mechanism of eukaryotic homologous recombination. Ann Rev Biochem 2008 ; 77 : 229–257. [CrossRef]
  5. Krejci L, Altmannova V, Spirek M, Zhao X. Homologous recombination and its regulation. Nucleic Acids Res 2012 ; 40 : 5795–5818. [CrossRef] [PubMed]
  6. West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003 ; 4 : 435–445. [CrossRef] [PubMed]
  7. Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer 2012 ; 12 : 68–78. [CrossRef]
  8. Yang H, Jeffrey PD, Miller J, et al. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 2002 ; 297 : 1837–1848. [CrossRef] [PubMed]
  9. Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat Struct Mol Biol 2010 ; 17 : 1260–1262. [CrossRef] [PubMed]
  10. Davies AA, Masson JY, McIlwraith MJ, et al. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell 2001 ; 7 : 273–282. [CrossRef] [PubMed]
  11. Carreira A, Kowalczykowski SC. Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms. Proc Natl Acad Sci USA 2011 ; 108 : 10448–10453. [CrossRef]
  12. Chen CF, Chen PL, Zhong Q, et al. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J Biol Chem 1999 ; 274 : 32931–32935. [CrossRef] [PubMed]
  13. Galkin VE, Esashi F, Yu X, et al. BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci USA 2005 ; 102 : 8537–8542. [CrossRef]
  14. Saeki H, Siaud N, Christ N, et al. Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc Natl Acad Sci USA 2006 ; 103 : 8768–8773. [CrossRef]
  15. Esashi F, Christ N, Gannon J, et al. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005 ; 434 : 598–604. [CrossRef] [PubMed]
  16. Esashi F, Galkin VE, Yu X, et al. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol 2007 ; 14 : 468–474. [CrossRef] [PubMed]
  17. Davies OR, Pellegrini L. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat Struct Mol Biol 2007 ; 14 : 475–483. [PubMed]
  18. Schlacher K, Christ N, Siaud N, et al. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 2011 ; 145 : 529–542. [CrossRef] [PubMed]
  19. Ayoub N, Rajendra E, Su X, et al. The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol 2009 ; 19 : 1075–1085. [CrossRef] [PubMed]
  20. Xia B, Sheng Q, Nakanishi K, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 2006 ; 22 : 719–729. [CrossRef] [PubMed]
  21. Tischkowitz M, Xia B. PALB2/FANCN: recombining cancer and Fanconi anemia. Cancer Res 2010 ; 70 : 7353–7359. [CrossRef] [PubMed]
  22. Zhang F, Ma J, Wu J, et al. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 2009 ; 19 : 524–529. [CrossRef] [PubMed]
  23. Buisson R, Masson JY. PALB2 self-interaction controls homologous recombination. Nucleic Acids Res 2012 ; 40 : 10312–10323. [CrossRef] [PubMed]
  24. Bleuyard JY, Buisson R, Masson JY, Esashi F. ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. EMBO Rep 2012 ; 13 : 135–141. [CrossRef] [PubMed]
  25. Buisson R, Dion-Cote AM, Coulombe Y, et al. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol 2010 ; 17 : 1247–1254. [CrossRef] [PubMed]
  26. Dray E, Etchin J, Wiese C, et al. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol 2010 ; 17 : 1255–1259. [CrossRef] [PubMed]
  27. Jensen RB, Carreira A, Kowalczykowski SC. Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 2010 ; 467 : 678–683. [CrossRef] [PubMed]
  28. Thorslund T, McIlwraith MJ, Compton SA, et al. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol 2010 ; 17 : 1263–1265. [CrossRef] [PubMed]
  29. Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007 ; 316 : 1160–1166. [CrossRef] [PubMed]
  30. Bunting SF, Callen E, Wong N, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010 ; 141 : 243–254. [CrossRef] [PubMed]
  31. Miné-Hattab J, Rothstein R. Réparation de l’ADN : comment trouver le bon partenaire ? Med sci (Paris) 2012 ; 28 : 714–716. [CrossRef] [EDP Sciences] [PubMed]

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