Free Access
Med Sci (Paris)
Volume 22, Number 3, Mars 2006
Page(s) 308 - 312
Section M/S revues
Published online 15 March 2006
  1. Ebbeling CB, Pawlak, D. Ludwig DS. Childhood obesity : public health crisis, common sense cure. Lancet 2002; 360 : 473–82. [Google Scholar]
  2. ObEpi. ObEpi 2003 : 3e enquête épidémiologique nationale sur l’obésité et le surpoids en France. Conférence de presse, Hôtel Dieu-Paris, 2003. [Google Scholar]
  3. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986; 256 : 51–4 [Google Scholar]
  4. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors. JAMA 2003; 289 : 76–9. [Google Scholar]
  5. Weill J, Vanderbecken S, Froguel P. Understanding the rising incidence of type 2 diabetes in adolescence. Arch Dis Child 2004; 89 : 502–4. [Google Scholar]
  6. Meyre D, Lecoeur C, Delplanque J, et al. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004; 53 : 803–11. [Google Scholar]
  7. Atwood LD, Heard-Costa NL, Cupples LA, et al. Genomewide linkage analysis of body mass index across 28 years of the Framingham heart study. Am J Hum Genet 2002; 71 : 1044–50. [Google Scholar]
  8. Duggirala R, Blangero J, Almasy L, et al. A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet 2001; 68 : 1149–64. [Google Scholar]
  9. Abney M, Ober C, McPeek MS. Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees : fasting serum- insulin level in the Hutterites. Am J Hum Genet 2002: 70 : 920–34. [Google Scholar]
  10. Ehm MG, Karnoub MC, Sakul H, et al. Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet 2000; 66 : 1871–81. [Google Scholar]
  11. Ghosh S, Watanabe RM, Valle TT, et al. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 2000; 67 : 1174–85. [Google Scholar]
  12. Demenais F, Kanninen T, Lindgren CM, et al. A meta-analysis of four European genome screens (GIFT consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. Hum Mol Genet 2003; 12 : 1865–73. [Google Scholar]
  13. Xiang K, Wang Y, Zheng T, et al. Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese : significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes 2004; 53 : 228–34. [Google Scholar]
  14. Maddux BA, Sbraccia P, Kumakura S, et al. Membrane glycoprotein PC-1 and insulin resistance in non-insulin- dependent diabetes mellitus. Nature 1995; 373 : 448–51. [Google Scholar]
  15. Maddux BA, Goldfine ID. Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 2000; 49 : 13–9. [Google Scholar]
  16. Costanzo BV, Trischitta V, Di Paola R, et al. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 2001; 50 : 831–6. [Google Scholar]
  17. Pizzuti A, Frittitta L, Argiolas A, et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999; 48 : 1881–4. [Google Scholar]
  18. Abate N, Carulli L, Cabo-Chan A, et al. Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. J Clin Endocrinol Metab 2003; 88 : 5927–34. [Google Scholar]
  19. Rutsch F, Vaingankar S, Johnson K, et al. PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol 2001; 158 : 543–54. [Google Scholar]
  20. Bacci S, Ludovico O, Prudente S, et al. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. Diabetes 2005; 54 : 3021–5. [Google Scholar]
  21. Meyre D, Bouatia-Naji N, Tounian A, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37 : 863–7. [Google Scholar]
  22. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392 : 398–401. [Google Scholar]
  23. Vaisse C, Clement K, Guy-Grand B, Froguel PA. Frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998; 20 : 113–4. [Google Scholar]
  24. Vaisse C, Clement K, Durand E, et al. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000; 10 : 253–62. [Google Scholar]
  25. Boutin P, Dina C, Vasseur F, et al. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLOS Biol 2003; 1 : 1–11. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.