Open Access
Tableau III.
Principales molécules antivirales ciblant le DENV. MTase : méthyl-transférase, RdRp : ARN polymérase-ARN dépendante.
| Protéine ciblée | Molécule antivirale | Étape/fonction cible | Référence | |||
|---|---|---|---|---|---|---|
| Structurales | E | dipeptide EF | [17] | |||
| peptide DN59 | [18] | |||||
| peptide MLH40 | Fusion/entrée du virus | [68] | ||||
| NITD448 | [69] | |||||
| A5 | [70] | |||||
| Composé 6 | [71] | |||||
| Géraniine | Fixation du virus | [72] | ||||
| C | Pep 14-23 | interaction C-ARN viral | [19] | |||
| VGTI-A3-03 | Assemblage des virions | [20] | ||||
| ST-610 | [73] | |||||
| NS3 | NS3 hélicase | Suramine | fonction hélicase | [23] | ||
| Ivermectine | [22] | |||||
| Protégrine-1 | [74] | |||||
| Rétrocycline-1 | [75] | |||||
| NS3 protéase | fonction protéase | |||||
| Nelfinavir | [76] | |||||
| 166347 | [77] | |||||
| AM404 | [27] | |||||
| Composé 14a | Inhibition de NS4B | [78] | ||||
| NS4B | NITD-618 | [29] | ||||
| Non-Structurales | JNJ-A07 | interaction NS4B-NS3 | [31] | |||
| JNJ-1802 | [30] | |||||
| Cordycépine | [33] | |||||
| bloquage du le site actif | ||||||
| NS5 | NS5 MTase | Sinéfugine | [34] | |||
| Hexasodium de Suramine | ||||||
| I-OMe-AG238 | interactions de NS5/ NS3 - importines | [35] | ||||
| HeE1-2Tyr | [79] | |||||
| Composé 27 | [80] | |||||
| NS5 RdRp | Composé 29 | ARN polymérase | ||||
| NITD008 | [81] | |||||
| Balapiravir | [82] | |||||
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