Tableau I.
Les molécules d’adhésion impliquées dans le recrutement lymphocytaire intestinal selon les différentes sections de l’intestin. MAdCAM-1 : mucosal cell adhesion molecule-1 ; VAP : vascular adhesion protein-1 ; PSGL-1 : P-selectin glycoprotein ligand-1 ; ICAM : intracellular adhesion molecule-1 ; VCAM-1 : vascular cell adhesion molecule-1 ; PNAd : peripheral node addressin.
| Compartiments | Roulement | Chimiokines et récepteurs | Adhésion : intégrines et ligands |
|---|---|---|---|
| Galt | α4β7-MAdCAM-1 | CCR6-CCL20 | α4β7-MAdCAM-1 |
| L-sélectine-MAdCAM-1 ou PSGL-1 | CCR7-CCL21/19 | VAP-1 | |
| CXCR5-CXCL13 | αLβ2-ICAM-1 | ||
| CXCR1-CX3CL1 | |||
| Lamina propria | α4β7-MAdCAM-1 | CCR2-CCL2/7/8 | α4β7-MAdCAM-1 |
| ε-sélectine | CCR5-CCL3/4/5/8 | VAP-1 | |
| P-sélectine + PSGL-1 | CCR6-CCL20 | α4β1-VCAM-1 | |
| CCR9-CCL25 | αLβ2-ICAM-1 | ||
| CCR10-CCL28 | |||
| CXCR1-CXCL5/6/8 | |||
| CXCR2-CXCL1/2/5/6 | |||
| CXCR3-CXCL9/10/11 | |||
| CXCR6-CXCL9/10/11 | |||
| CXCR6-CXCL16 | |||
| CX3CR1-CX3CL1 | |||
| CCR9-CCL25 | |||
| Compartiment intraépithélial | CCR10-CCL28 | αεβ7-ε Cadhérine-1 | |
| Côlon | α4β7-MAdCAM-1 | CCR3-CCL11 (UC) | VAP-1 |
| ε-sélectine | CCR5-CCL3/7/5/8 | α4β1-VCAM-1 | |
| P-sélectine + PSGL-1 | CCR6-CCL20 | αLβ2-ICAM-1 | |
| L-sélectine + PNAd | CCR10-CCL28 | αLb2-ICAM-1 | |
| CXCR1-CXCL5/6/8 | |||
| CXCR2-CXCL1/2/5/6 | |||
| CXCR3-CXCL9/10/11 | |||
| CX3CR1-CX3CL1 | |||
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