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Tableau I.
Caractéristiques des trois principaux vecteurs viraux utilisés en thérapie génique oculaire. kb : kilobases.
| Vecteur viral | Génome viral | Taille maximale de la cassette d’expression | Enveloppe | Propriétés immunogènes |
|---|---|---|---|---|
| Adénovirus | ADN double brin | 36 kb | Non | Oui |
| Lentivirus | ARN double brin | 10 kb | Oui | Oui |
| Virus adéno-associé (AAV) | ADN simple brin | < 5 kb | Non | Minimes |
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