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Tableau III

Composés agonistes en cours de développement ciblant TLR8.

Cible des agonistes Nom Compagnie Indication Statut de l’essai
TLR8 VTX-1463 VantiRX Pharmaceuticals Inc. Rhinite allergique Phase I
TLR8 VTX-2337 VantiRX Pharmaceuticals Inc. Cancer Phase I
TLR7, TLR8 et TLR9 CPG 52364 Pfizer Lupus érythémateux disséminé Phase I
TLR7 et TLR8 Resiquimod 3M Pharmaceuticals Hépatite C, herpès Suspendu en phase III
TLR7 et TLR8 IMO-4020 Idera Pharmaceuticals Lymphome Préclinique
TLR7, TLR8 et TLR9 Adjuvant vaccinal Idera Pharmaceuticals Maladies infectieuses, cancer, maladie d’Alzheimer Préclinique
TLR7 et TLR8 VTX-463 Array BioPharma Allergie Préclinique
TLR8 VTX-763 VantiRX Pharmaceuticals Inc. Inflammation auto-immune Préclinique
TLR7 et TLR8 IPH 3201 Innate Pharma Adjuvant vaccinal Préclinique

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