| Issue |
Med Sci (Paris)
Volume 31, Number 6-7, Juin–Juillet 2015
|
|
|---|---|---|
| Page(s) | 691 - 695 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/20153106025 | |
| Published online | 07 July 2015 | |
Thérapie génique germinale, le retour ?
Chroniques génomiques
The return of germline gene therapy
1
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hospital d’adultes la Timone, 264, rue Saint-Pierre, 13385
Marseille Cedex 05, France
2
CoReBio PACA, case 901, parc scientifique de Luminy, 13288
Marseille Cedex 09, France
*
bertrand.jordan@univ-amu.fr ; brjordan@orange.fr
Abstract
The recent development of a powerful and flexible genome editing technique (the CRISP-cas9 method) accelerates tremendously the production of animal models and will significantly enhance the perspectives of (somatic) gene therapy. However, it also raises a real possibility of germline modifications in humans, with therapeutic aims or for “improvement”: this raises thorny ethical questions that are no longer theoretical (as in the 1990s) but will have to be faced in the very near future.
© 2015 médecine/sciences – Inserm
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