Thérapie génique germinale, le retour ?
The return of germline gene therapy
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hospital d’adultes la Timone, 264, rue Saint-Pierre, 13385
Marseille Cedex 05, France
2 CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France
The recent development of a powerful and flexible genome editing technique (the CRISP-cas9 method) accelerates tremendously the production of animal models and will significantly enhance the perspectives of (somatic) gene therapy. However, it also raises a real possibility of germline modifications in humans, with therapeutic aims or for “improvement”: this raises thorny ethical questions that are no longer theoretical (as in the 1990s) but will have to be faced in the very near future.
© 2015 médecine/sciences – Inserm