Issue |
Med Sci (Paris)
Volume 27, Number 8-9, Août–Septembre 2011
|
|
---|---|---|
Page(s) | 746 - 752 | |
Section | M/S Revues | |
DOI | https://doi.org/10.1051/medsci/2011278017 | |
Published online | 31 August 2011 |
Une protéine uNick en son genre
A uNick protein
Laboratoire des polypeptides, Faculté de médecine, Université McGill, édifice Strathcona, 3640, rue University, W315, Montréal, Québec, H3A 2B2 Canada
*
mélissa.labelle-cote@umontreal.ca
**
louise.larose@mcgill.ca
Nck, représenté par Nck1 et Nck2, est un adaptateur à domaines homologues de Src (SH2 et SH3), unique compte tenu de la diversité des processus cellulaires morphogéniques et mitogéniques auxquels il participe et de ses modes atypiques de signalisation. Son rôle-clé au centre de plusieurs voies de signalisation laisse présager qu’une variation de ses niveaux d’expression pourrait altérer l’homéostasie des cellules. En accord avec cette hypothèse, une augmentation de l’expression de Nck1 et Nck2 a été observée dans de nombreux types de cancer. Nous décrivons ici certains des complexes signalétiques associés à Nck, en mettant l’accent sur les mécanismes moléculaires par lesquels cet adaptateur unique peut contribuer au cancer.
Abstract
Nck is an adaptor protein composed of three N-terminal Src Homology (SH) 3 domains followed by a unique C‑terminal SH2 domain. Like other SH2/SH3 domains-containing adaptor proteins, Nck mediates signal transduction from activated cell surface receptors by directing the flow of information to elicit properly orchestrated cell responses. In this way, Nck appears to be unique in its contribution to a wide variety of cellular processes. Moreover, in addition to the typical signal/pY-SH2/SH3-effectors mode of signaling, Nck also transduces signals through an inverse mode of signaling (signal-SH3/SH2-pY/effectors) and from various cell compartments. Since Nck contributes to important morphogenic and mitogenic processes, deregulated expression of Nck could be detrimental to cellular homeostasis. In agreement, Nck expression has been found upregulated in numerous types of cancer. In this paper we delineate the main molecular signaling complexes associated with Nck, focusing on those involved in cancer progression.
© 2011 médecine/sciences – Inserm / SRMS
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