Open Access
Numéro
Med Sci (Paris)
Volume 36, Numéro 10, Octobre 2020
Page(s) 859 - 865
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2020156
Publié en ligne 7 octobre 2020
  1. Matta J, Zins M, Feral-Pierssens A, et al. Prévalence du surpoids, de l’obésité et des facteurs de risque cardio-métaboliques dans la cohorte Constances. Bull Epidémiol Hebd 2016 ; 35–36 : 640–646. [Google Scholar]
  2. Global BMI Mortality Collaboration, Di Angelantonio E, Bhupathiraju SN, Wormser D, et al. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet 2016 ; 388 : 776–786. [CrossRef] [PubMed] [Google Scholar]
  3. Simonnet A, Chetboun M, Poissy J, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity (Silver Spring) 2020; 28(7) : 1195–9. [Google Scholar]
  4. Wardle J, Carnell S, Haworth CM, et al. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 2008 ; 87 : 398–404. [CrossRef] [PubMed] [Google Scholar]
  5. Yengo L, Sidorenko J, Kemper KE, et al. Meta-analysis of genome-wide association studies for height and body mass index in ≈700000 individuals of European ancestry. Hum Mol Genet 2018 ; 27 : 3641–3649. [CrossRef] [PubMed] [Google Scholar]
  6. Ndiaye FK, Huyvaert M, Ortalli A, et al. The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward. Int J Obes (Lond) 2020; 44 : 539–43. [CrossRef] [PubMed] [Google Scholar]
  7. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994 ; 372 : 425–432. [CrossRef] [PubMed] [Google Scholar]
  8. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995 ; 1 : 1155–1161. [CrossRef] [PubMed] [Google Scholar]
  9. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997 ; 387 : 903–908. [CrossRef] [PubMed] [Google Scholar]
  10. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998 ; 392 : 398–401. [CrossRef] [PubMed] [Google Scholar]
  11. Ellacott KLJ, Cone RD The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philos Trans R Soc Lond, B, Biol Sc 2006 ; 361 : 1265–1274. [CrossRef] [Google Scholar]
  12. Morton GJ, Cummings DE, Baskin DG, et al. Central nervous system control of food intake and body weight. Nature 2006 ; 443 : 289–295. [CrossRef] [PubMed] [Google Scholar]
  13. Arora S Anubhuti null. Role of neuropeptides in appetite regulation and obesity: a review. Neuropeptides 2006 ; 40 : 375–401. [CrossRef] [PubMed] [Google Scholar]
  14. Vaisse C, Clement K, Guy-Grand B, et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998 ; 20 : 113–114. [Google Scholar]
  15. Yeo GS, Farooqi IS, Aminian S, et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998 ; 20 : 111–112. [Google Scholar]
  16. Stutzmann F, Tan K, Vatin V, et al. Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees. Diabetes 2008 ; 57 : 2511–2518. [CrossRef] [PubMed] [Google Scholar]
  17. Saeed S, Arslan M, Froguel P Genetics of obesity in consanguineous populations: toward precision medicine and the discovery of novel obesity genes. Obesity (Silver Spring) 2018 ; 26 : 474–484. [Google Scholar]
  18. Dubern B, Bisbis S, Talbaoui H, et al. Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity. J Pediatr 2007; 150 : 6137, 617.e1. [Google Scholar]
  19. Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998 ; 19 : 155–157. [Google Scholar]
  20. O’Rahilly S, Gray H, Humphreys PJ, et al. Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. N Engl J Med 1995 ; 333 : 1386–1390. [Google Scholar]
  21. Philippe J, Stijnen P, Meyre D, et al. A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity. Int J Obes 2015 ; 39 : 295–302. [CrossRef] [PubMed] [Google Scholar]
  22. Tolson KP, Gemelli T, Gautron L, et al. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosc. 2010 ; 30 : 3803–3812. [CrossRef] [Google Scholar]
  23. Bonnefond A, Raimondo A, Stutzmann F, et al. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. J Clin Invest 2013 ; 123 : 3037–3041. [CrossRef] [PubMed] [Google Scholar]
  24. Ramachandrappa S, Raimondo A, Cali AMG, et al. Rare variants in single-minded 1 (SIM1) are associated with severe obesity. J Clin Invest 2013 ; 123 : 3042–3050. [CrossRef] [PubMed] [Google Scholar]
  25. Yeo GSH, Connie Hung CC, Rochford J, et al. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004 ; 7 : 1187–1189. [CrossRef] [PubMed] [Google Scholar]
  26. Gray J, Yeo G, Hung C, et al. Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Int J Obes (Lond) 2007 ; 31 : 359–364. [CrossRef] [PubMed] [Google Scholar]
  27. Gray J, Yeo GSH, Cox JJ, et al. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 2006 ; 55 : 3366–3371. [CrossRef] [PubMed] [Google Scholar]
  28. Serra-Juhé C, Martos-Moreno GÁ, Bou de Pieri F, et al. Heterozygous rare genetic variants in non-syndromic early-onset obesity. Int J Obes (Lond) 2020; 44 : 830–41. [CrossRef] [PubMed] [Google Scholar]
  29. Doche ME, Bochukova EG, Su H-W, et al. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. J Clin Invest 2012 ; 122 : 4732–4736. [CrossRef] [PubMed] [Google Scholar]
  30. Siljee JE, Wang Y, Bernard AA, et al. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet 2018 ; 50 : 180–185. [Google Scholar]
  31. Saeed S, Bonnefond A, Tamanini F, et al. Loss-of-function mutations in ADCY3 cause monogenic severe obesity. Nat Genet 2018 ; 50 : 175–179. [Google Scholar]
  32. Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999 ; 341 : 879–884. [Google Scholar]
  33. Kühnen P, Clément K, Wiegand S, et al. Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist. N Engl J Med 2016 ; 375 : 240–246. [Google Scholar]
  34. Clément K, Biebermann H, Farooqi IS, et al. MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nat Med 2018 ; 24 : 551–555. [CrossRef] [PubMed] [Google Scholar]
  35. Collet TH, Dubern B, Mokrosinski J, et al. Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency. Mol Metab 2017 ; 6 : 1321–1329. [CrossRef] [PubMed] [Google Scholar]
  36. Montagne L, Derhourhi M, Piton A, et al. CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability. Mol Metab 2018 ; 13 : 1–9. [CrossRef] [PubMed] [Google Scholar]
  37. Chan LF, Webb TR, Chung TT, et al. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci USA 2009 ; 106 : 6146–6151. [CrossRef] [Google Scholar]
  38. Asai M, Ramachandrappa S, Joachim M, et al. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science 2013 ; 341 : 275–278. [Google Scholar]
  39. Sebag JA, Zhang C, Hinkle PM, et al. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 2013 ; 341 : 278–281. [Google Scholar]
  40. Baron M, Maillet J, Huyvaert M, et al. Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension. Nat Med 2019 ; 25 : 1733–1738. [CrossRef] [PubMed] [Google Scholar]

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.