EDP Sciences logo
Authentification abonné
Rechercher
Menu
Accueil Tous les numéros Volume 36 / Numéro 5 (Mai 2020) Med Sci (Paris), 36 5 (2020) 487-496 Références
Open Access
Numéro
Med Sci (Paris)
Volume 36, Numéro 5, Mai 2020
Page(s) 487 - 496
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2020080
Publié en ligne 26 mai 2020
  1. Kawasaki T, Kitsukawa T, Bekku Y, et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 1999 ; 126 : 4895–4902. [PubMed] [Google Scholar]
  2. Kitsukawa T, Shimono A, Kawakami A, et al. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 1995 ; 121 : 4309–4318. [PubMed] [Google Scholar]
  3. Yuan L, Moyon D, Pardanaud L, et al. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 2002 ; 129 : 4797–4806. [PubMed] [Google Scholar]
  4. Takashima S, Kitakaze M, Asakura M, et al. Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci USA 2002 ; 99 : 3657–3662. [CrossRef] [Google Scholar]
  5. Valdembri D, Caswell PT, Anderson KI, et al. Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol 2009 ; 7 : e25. [CrossRef] [PubMed] [Google Scholar]
  6. Wang L, Mukhopadhyay D, Xu X. C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB J 2006 ; 20 : 1513–1515. [CrossRef] [PubMed] [Google Scholar]
  7. Cao Y, E G, Wang E, et al. VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res 2012 ; 72 : 3912–3918. [Google Scholar]
  8. Roy S, Bag AK, Singh RK, et al. Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy. Front Immunol 2017 ; 8 : 1228. [CrossRef] [PubMed] [Google Scholar]
  9. Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics?. Nat Rev Cancer 2008 ; 8 : 880–887. [Google Scholar]
  10. Balan M, Mier y Teran E, Waaga-Gasser AM, et al. Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression. J Biol Chem 2015 ; 290 : 8110–8120. [CrossRef] [PubMed] [Google Scholar]
  11. Cao Y, Wang L, Nandy D, et al. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res 2008 ; 68 : 8667–8672. [Google Scholar]
  12. Lepelletier Y, Moura IC, Hadj-Slimane R, et al. Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization. Eur J Immunol 2006 ; 36 : 1782–1793. [CrossRef] [PubMed] [Google Scholar]
  13. Schellenburg S, Schulz A, Poitz DM, Muders MH. Role of neuropilin-2 in the immune system. Mol Immunol 2017 ; 90 : 239–244. [Google Scholar]
  14. Curreli S, Arany Z, Gerardy-Schahn R, et al. Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions. J Biol Chem 2007 ; 282 : 30346–30356. [CrossRef] [PubMed] [Google Scholar]
  15. Casazza A, Laoui D, Wenes M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 2013 ; 24 : 695–709. [CrossRef] [PubMed] [Google Scholar]
  16. Cherry JD, Olschowka JA, O’Banion MK. Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation 2014 ; 11 : 98. [CrossRef] [PubMed] [Google Scholar]
  17. Stamatos NM, Zhang L, Jokilammi A, et al. Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis. Glycobiology 2014 ; 24 : 864–879. [CrossRef] [PubMed] [Google Scholar]
  18. Hong TM, Chen YL, Wu YY, et al. Targeting neuropilin 1 as an antitumor strategy in lung cancer. Clin Cancer Res 2007 ; 13 : 4759–4768. [CrossRef] [PubMed] [Google Scholar]
  19. Gray MJ, Van Buren G, Dallas NA, et al. Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst 2008 ; 100 : 109–120. [CrossRef] [PubMed] [Google Scholar]
  20. Cao Y, Hoeppner LH, Bach S, et al. Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial alpha5 integrin. Cancer Res 2013 ; 73 : 4579–4590. [Google Scholar]
  21. Weekes CD, Beeram M, Tolcher AW, et al. A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors. Invest New Drugs 2014 ; 32 : 653–660. [CrossRef] [PubMed] [Google Scholar]
  22. Liang WC, Dennis MS, Stawicki S, et al. Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library. J Mol Biol 2007 ; 366 : 815–829. [Google Scholar]
  23. Pan Q, Chanthery Y, Liang WC, et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 2007 ; 11 : 53–67. [CrossRef] [PubMed] [Google Scholar]
  24. Patnaik A, LoRusso PM, Messersmith WA, et al. A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 2014 ; 73 : 951–960. [CrossRef] [PubMed] [Google Scholar]
  25. Tse BWC, Volpert M, Ratther E, et al. Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene 2017 ; 36 : 3417–3427. [Google Scholar]
  26. Parker MW, Xu P, Li X, Vander Kooi CW. Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem 2012 ; 287 : 11082–11089. [CrossRef] [PubMed] [Google Scholar]
  27. Starzec A, Vassy R, Martin A, et al. Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1. Life Sci 2006 ; 79 : 2370–2381. [CrossRef] [PubMed] [Google Scholar]
  28. Tirand L, Frochot C, Vanderesse R, et al. A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells. J Control Release 2006 ; 111 : 153–164. [CrossRef] [PubMed] [Google Scholar]
  29. Benachour H, Seve A, Bastogne T, et al. Multifunctional Peptide-conjugated hybrid silica nanoparticles for photodynamic therapy and MRI. Theranostics 2012 ; 2 : 889–904. [CrossRef] [PubMed] [Google Scholar]
  30. Richard M, Chateau A, Jelsch C, et al. Carbohydrate-based peptidomimetics targeting neuropilin-1: synthesis, molecular docking study and in vitro biological activities. Bioorg Med Chem 2016 ; 24 : 5315–5325. [CrossRef] [PubMed] [Google Scholar]
  31. Puszko AK, Sosnowski P, Tymecka D, et al. Neuropilin-1 peptide-like ligands with proline mimetics, tested using the improved chemiluminescence affinity detection method. Medchemcomm 2019 ; 10 : 332–340. [CrossRef] [PubMed] [Google Scholar]
  32. Jia H, Bagherzadeh A, Hartzoulakis B, et al. Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling. J Biol Chem 2006 ; 281 : 13493–13502. [CrossRef] [PubMed] [Google Scholar]
  33. Jarvis A, Allerston CK, Jia H, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem 2010 ; 53 : 2215–2226. [CrossRef] [PubMed] [Google Scholar]
  34. Powell J, Mota F, Steadman D, et al. Small molecule neuropilin-1 antagonists combine antiangiogenic and antitumor activity with immune modulation through reduction of transforming growth factor beta (TGFbeta) production in regulatory T-cells. J Med Chem 2018 ; 61 : 4135–4154. [CrossRef] [PubMed] [Google Scholar]
  35. Starzec A, Miteva MA, Ladam P, et al. Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening. Bioorg Med Chem 2014 ; 22 : 4042–4048. [CrossRef] [PubMed] [Google Scholar]
  36. Liu WQ, Megale V, Borriello L, et al. Synthesis and structure-activity relationship of non-peptidic antagonists of neuropilin-1 receptor. Bioorg Med Chem Lett 2014 ; 24 : 4254–4259. [PubMed] [Google Scholar]
  37. Liu WQ, Lepelletier Y, Montes M, et al. NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model. Cancer Lett 2018 ; 414 : 88–98. [Google Scholar]
  38. Borriello L, Montes M, Lepelletier Y, et al. Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model. Cancer Lett 2014 ; 349 : 120–127. [Google Scholar]
  39. Brachet E, Dumond A, Liu WQ, et al. Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent. Bioorg Med Chem Lett 2019 ; 29 : 126710. [PubMed] [Google Scholar]
  40. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000 ; 100 : 57–70. [CrossRef] [PubMed] [Google Scholar]
  41. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011 ; 144 : 646–674. [CrossRef] [PubMed] [Google Scholar]

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.