Le déséquilibre élastase/α1-antitrypsine - Un nouvel acteur dans le processus d’obésité et de son syndrome métabolique

Virginie Mansuy-Aubert

doi:10.1051/medsci/20132910006

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Volume 29 / Numéro 10 (Octobre 2013)

Med Sci (Paris), 29 10 (2013) 831-833

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Numéro		Med Sci (Paris) Volume 29, Numéro 10, Octobre 2013


Page(s)		831 - 833
Section		Nouvelles
DOI		https://doi.org/10.1051/medsci/20132910006
Publié en ligne		18 octobre 2013

Davis TM, Ee CK. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004 ; 351 : 1146–1148. [CrossRef] [Google Scholar]
Prasad H, Ryan DA, Celzo MF, Stapleton D. Metabolic syndrome: definition and therapeutic implications. Postgrad Med 2012 ; 124 : 21–30. [CrossRef] [Google Scholar]
Grundy SM, Brewer HB, Jr, Cleeman JI, et al. Definition of metabolic syndrome: report of the National heart, lung, and blood institute/American heart association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 2004 ; 24 : e13–e18. [CrossRef] [PubMed] [Google Scholar]
Johnson AM, Olefsky JM. The origins and drivers of insulin resistance. Cell 2013 ; 152 : 673–684. [CrossRef] [PubMed] [Google Scholar]
Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 2012 ; 15 : 635–645. [CrossRef] [PubMed] [Google Scholar]
Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Ann Rev Physiol 2010 ; 72 : 219–246. [CrossRef] [PubMed] [Google Scholar]
Lu M, Patsouris D, Li P, et al. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2010 ; 298 : E1036–E1048. [CrossRef] [PubMed] [Google Scholar]
Jiao J, Bae EJ, Bandyopadhyay G, et al. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes 2013 ; 62 : 1074–1083. [CrossRef] [PubMed] [Google Scholar]
Oh DY, Morinaga H, Talukdar S, et al. Increased macrophage migration into adipose tissue in obese mice. Diabetes 2012 ; 61 : 346–354. [CrossRef] [PubMed] [Google Scholar]
Osborn O, Sears DD, Olefsky JM. Fat-induced inflammation unchecked. Cell Metab 2010 ; 12 : 553–554. [CrossRef] [PubMed] [Google Scholar]
Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia 2012 ; 55 : 2583–2592. [CrossRef] [PubMed] [Google Scholar]
Luciani A, Dechoux S, Deveaux V, et al. Adipose tissue macrophages: MR tracking to monitor obesity-associated inflammation. Radiology 2012 ; 263 : 786–793. [CrossRef] [PubMed] [Google Scholar]
Mansuy-Aubert V, Zhou QL, Xie X, et al. Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 2013 ; 17 : 534–548. [CrossRef] [PubMed] [Google Scholar]
Franc C. Le diabète : des chiffres alarmants. Med Sci (Paris) 2013 ; 29 : 711–714. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
Carrière A, Jeanson Y., Cousin B., Arnaud E., Casteilla L. Le recrutement et l’activation d’adipocytes bruns et/ou BRITE : une perspective réelle pour le traitement des maladies métaboliques ? Med Sci (Paris) 2013 ; 29 : 729–735. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

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[1] Davis TM, Ee CK. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004 ; 351 : 1146–1148. [CrossRef] [Google Scholar]

[2] Prasad H, Ryan DA, Celzo MF, Stapleton D. Metabolic syndrome: definition and therapeutic implications. Postgrad Med 2012 ; 124 : 21–30. [CrossRef] [Google Scholar]

[3] Grundy SM, Brewer HB, Jr, Cleeman JI, et al. Definition of metabolic syndrome: report of the National heart, lung, and blood institute/American heart association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 2004 ; 24 : e13–e18. [CrossRef] [PubMed] [Google Scholar]

[4] Johnson AM, Olefsky JM. The origins and drivers of insulin resistance. Cell 2013 ; 152 : 673–684. [CrossRef] [PubMed] [Google Scholar]

[5] Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 2012 ; 15 : 635–645. [CrossRef] [PubMed] [Google Scholar]

[6] Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Ann Rev Physiol 2010 ; 72 : 219–246. [CrossRef] [PubMed] [Google Scholar]

[7] Lu M, Patsouris D, Li P, et al. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2010 ; 298 : E1036–E1048. [CrossRef] [PubMed] [Google Scholar]

[8] Jiao J, Bae EJ, Bandyopadhyay G, et al. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes 2013 ; 62 : 1074–1083. [CrossRef] [PubMed] [Google Scholar]

[9] Oh DY, Morinaga H, Talukdar S, et al. Increased macrophage migration into adipose tissue in obese mice. Diabetes 2012 ; 61 : 346–354. [CrossRef] [PubMed] [Google Scholar]

[10] Osborn O, Sears DD, Olefsky JM. Fat-induced inflammation unchecked. Cell Metab 2010 ; 12 : 553–554. [CrossRef] [PubMed] [Google Scholar]

[11] Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia 2012 ; 55 : 2583–2592. [CrossRef] [PubMed] [Google Scholar]

[12] Luciani A, Dechoux S, Deveaux V, et al. Adipose tissue macrophages: MR tracking to monitor obesity-associated inflammation. Radiology 2012 ; 263 : 786–793. [CrossRef] [PubMed] [Google Scholar]

[13] Mansuy-Aubert V, Zhou QL, Xie X, et al. Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 2013 ; 17 : 534–548. [CrossRef] [PubMed] [Google Scholar]

[14] Franc C. Le diabète : des chiffres alarmants. Med Sci (Paris) 2013 ; 29 : 711–714. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]

[15] Carrière A, Jeanson Y., Cousin B., Arnaud E., Casteilla L. Le recrutement et l’activation d’adipocytes bruns et/ou BRITE : une perspective réelle pour le traitement des maladies métaboliques ? Med Sci (Paris) 2013 ; 29 : 729–735. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]