Détermination du sexe des mammifères : la mise à jour d’un trafic?

Stéphan Gasca; Brigitte Boizet-Bonhoure; Francis Poulat; Philippe Berta

doi:10.1051/medsci/200319125

Accès gratuit

Numéro		Med Sci (Paris) Volume 19, Numéro 1, Janvier 2003


Page(s)		25 - 26
Section		Le Magazine : Nouvelles
DOI		https://doi.org/10.1051/medsci/200319125
Publié en ligne		15 janvier 2003

The genetics and biology of sex determination. In: Chadwick D, Goode J, eds. Novartis found symposium 244. London: John Wiley and Sons Ltd, 2002 : 266 p. [Google Scholar]
Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346: 240–4. [Google Scholar]
Schmahl J, Eicher EM, Washburn LL, Capel B. Sry induces cell proliferation in the mouse gonad. Development 2000; 127: 65–73. [Google Scholar]
Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 2000; 227: 239–55. [Google Scholar]
De Santa Barbara P, Bonneaud N, Boizet B, et al. Direct interaction of SRYrelated protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol Cell Biol 1998; 18: 6653–65. [Google Scholar]
Arango NA, Lovell-Badge R, Behringer RR. Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell 1999; 99: 409–19. [Google Scholar]
Morais da Silva S, Hacker A, Harley V, Goodfellow P, Swain A, Lovell-Badge R. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 1996; 14: 62–8. [Google Scholar]
Sudbeck P, Scherer G. Two independent nuclear localization signals are present in the DNA- binding high-mobility group domains of SRY and SOX9. J Biol Chem 1997; 272: 27848–52. [Google Scholar]
De Santa Barbara P, Moniot B, Poulat F, Berta P. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 2000; 217: 293–8. [Google Scholar]
Gasca S, Cañizares J, de Santa Barbara P, et al. A nuclear export signal within the HMG domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proc Natl Acad Sci USA 2002; 99: 11199–204. [Google Scholar]

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[1] The genetics and biology of sex determination. In: Chadwick D, Goode J, eds. Novartis found symposium 244. London: John Wiley and Sons Ltd, 2002 : 266 p. [Google Scholar]

[2] Sinclair AH, Berta P, Palmer MS, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346: 240–4. [Google Scholar]

[3] Schmahl J, Eicher EM, Washburn LL, Capel B. Sry induces cell proliferation in the mouse gonad. Development 2000; 127: 65–73. [Google Scholar]

[4] Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 2000; 227: 239–55. [Google Scholar]

[5] De Santa Barbara P, Bonneaud N, Boizet B, et al. Direct interaction of SRYrelated protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol Cell Biol 1998; 18: 6653–65. [Google Scholar]

[6] Arango NA, Lovell-Badge R, Behringer RR. Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell 1999; 99: 409–19. [Google Scholar]

[7] Morais da Silva S, Hacker A, Harley V, Goodfellow P, Swain A, Lovell-Badge R. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 1996; 14: 62–8. [Google Scholar]

[8] Sudbeck P, Scherer G. Two independent nuclear localization signals are present in the DNA- binding high-mobility group domains of SRY and SOX9. J Biol Chem 1997; 272: 27848–52. [Google Scholar]

[9] De Santa Barbara P, Moniot B, Poulat F, Berta P. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 2000; 217: 293–8. [Google Scholar]

[10] Gasca S, Cañizares J, de Santa Barbara P, et al. A nuclear export signal within the HMG domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proc Natl Acad Sci USA 2002; 99: 11199–204. [Google Scholar]