Accès gratuit
Numéro
Med Sci (Paris)
Volume 18, Numéro 1, Janvier 2002
Page(s) 86 - 90
Section M/S Revues : Mini-Synthéses
DOI https://doi.org/10.1051/medsci/200218186
Publié en ligne 15 janvier 2002
  1. Martucci CP, Fishman J. P450 enzymes of estrogen metabolism. Pharmacol Ther 1993; 57 : 237–57. [Google Scholar]
  2. Ozawa Y Higashiyama T, Shimizu Y, Yarborough C. Multiple functions of aro-matase and the active site structure; aromatase is the placental estrogen 2-hydroxylase. J Steroid Biochem Mol Biol 1993; 44 : 469–80. [Google Scholar]
  3. Weisz J, Bui QD, Roy D, Liehr JG. Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens. Endocrinology 1992; 131 : 655–61. [Google Scholar]
  4. Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 1996; 93: 9776–81. [Google Scholar]
  5. Stresser DM, Kupfer D. Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-Odemethylated methoxychlor. Biochemistry 1997; 36 : 2203–10. [Google Scholar]
  6. Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D. Estrogens as endogenous genotoxic agents-DNA adducts and mutations.J Natl Cancer Inst Monogr 2000; 27 : 75–93. [Google Scholar]
  7. Yager JD. Endogenous estrogens as carcinogens through metabolic activation. J Natl Cancer Inst Monogr 2000; 27: 67–73. [Google Scholar]
  8. Liehr JG, Roy D, Ari-Ulubelen A, Bui QD, Weisz J, Strobel HW. Effect of chronic estrogen treatment of Syrian hamsters on microsomal enzymes mediating formation of catecholestrogens and their redox cycling: implications for carcinoge-nesis. J Steroid Biochem 1990; 35 : 555–60. [Google Scholar]
  9. Yager JD, Liehr JG. Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 1996; 36 : 203–32. [Google Scholar]
  10. Wang MY, Liehr JG. Identification of fatty acid hydroperoxide cofactors in the cytochrome P450-mediated oxidation of estrogens to quinone metabolites. Rôle and balance of lipid peroxides during estrogen-induced carcinogenesis.J Biol Chem 1994; 269, 284–91. [Google Scholar]
  11. Roy D, Strobel HW, Liehr JG. Cytochrome b5-mediated redox cycling of estrogen. Arch Biochem Biophys 1991; 285; 331–8. [Google Scholar]
  12. Li JJ, Li SA. Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism. Fed Proc 1987; 46 : 1858–63. [Google Scholar]
  13. Liehr JG, Fang WF, Sirbasku DA, Ari-Ulubelen A. Carcinogenicity of catechol estrogens in Syrian hamsters. J Steroid Biochem 1986; 24 : 353–6. [Google Scholar]
  14. Cavalieri EL, Stack DE, Devanesan PD, et al. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc Natl Acad Sci USA 1997; 94 : 10937–42. [Google Scholar]
  15. Liehr JG, Ricci MJ, Jefcoate CR, Hannigan EV, Hokanson JA, Zhu BT. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci USA 1995; 92 : 9220–4. [Google Scholar]
  16. Liehr JG, Ricci MJ. 4-Hydroxylation of estrogens as marker of human mammary tumors.Proc Natl Acad Sci USA 1996; 93 : 3294–6. [Google Scholar]
  17. Han X, Liehr JG. Microsomemediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis 1995; 16 : 2571–4. [Google Scholar]
  18. Creveling, C.R. Catechol-omethyltransferase: factors relating to the carcinogenic potential of catecholestrogens. Polycyclic Aromatic Compounds 1994; 125. [Google Scholar]
  19. Roy D, Weisz J, Liehr JG. The O-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: implications for estrogeninduced carcinogenesis. Carcinogenesis 1990; 11 : 459–62. [Google Scholar]
  20. Lesca P,Pineau T. Toxicité de la dioxine : rÔle des protéines “PAS”. Med Sci 1999; 15 : 1379–87 [Google Scholar]
  21. Coumoul X, Diry M, Robillot C, Barouki R. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res 2001; 61 : 3942–8. [Google Scholar]
  22. Lucier GW, Tritscher A, Goldsworthy T, et al. Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res 1991; 51 : 1391–7. [Google Scholar]
  23. Tritscher AM, Seacat AM, Yager JD, et al. Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomi-zed rats. Cancer Lett 1996; 98 : 219–25. [Google Scholar]
  24. Jefcoate CR, Liehr JG, Santen RJ, et al. Tissuespecific synthesis and oxidative metabolism of estrogens.J Natl Cancer Inst Monogr 2000; 27 : 95–112. [Google Scholar]
  25. Bradlow HL, Hershcopf R, Martucci C, Fishman J. 16 alpha-hydroxylation of estradiol: a possible risk marker for breast cancer. Ann NY Acad Sci 1986; 464: 138–51. [Google Scholar]

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