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Tableau I.
Les cellules de l’immunité dans le tissu adipeux. 1Sélection de marqueurs couramment utilisés. 2Marqueurs d’activation M1 ou M2 associés aux marqueurs de macrophages, CD68 ou CD14 chez l’homme et F4/80 chez les rongeurs.
| Système immunitaire | Cellules de l’immunité | Marqueurs1 | Effet de l’obésité | Références | |
|---|---|---|---|---|---|
| Type cellulaire | Phénotype | ||||
| Inné | Macrophages | CD68, CD14, F4/80 | ↑ | [1-3, 23, 38, 40] | |
| M12 | CD40, CD11c, CD86, Mincle | ↑ | [17, 27, 32, 33, 35, 36] | ||
| M22 | CD206, CD163, CD209 | ↑ ↔ | [17, 27, 32] | ||
| Mixte M1 M2 | ↑ | [29-31] | |||
| Neutrophiles | NIMP-R-14 | ↑ | [9] | ||
| Mastocytes | Tryptase, chymase | ↑ | [11] | ||
| Interface | NKT | CD3 et CD56, NK1.1 | ↑ | [10] | |
| Adaptatif | Lymphocytes T | CD3 | ↑ | [13-16] | |
| Cytotoxiques | CD3 et CD8 | ↑ | [13, 14, 16] | ||
| Auxiliaires | CD3 et CD4 | ↑ ↓ | [13, 14, 16] | ||
| TH1 | CD3 et CD4 et IFNγ | ↑ | [14] | ||
| TH2 | CD3 et CD4 et Gata3 | ↔ | [14] | ||
| Treg | CD3 et CD4 et Foxp3, CD25 | ↓ | [13-15] | ||
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