Open Access
Issue
Med Sci (Paris)
Volume 41, Number 10, Octobre 2025
Page(s) 753 - 759
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2025141
Published online 19 November 2025
  1. Fiscutean A. Clarifying the burden of ovarian cancer. Nature 2021 ; 600 : S48–9. [Google Scholar]
  2. Arnaoutoglou C, Dampala K, Anthoulakis C, et al. Epithelial ovarian cancer: a five year review. Medicina 2023 ; 59 : 1183. [Google Scholar]
  3. Sambasivan S. Epithelial ovarian cancer: review article. Cancer Treat Res Commun 2022 ; 33 : 100629. [Google Scholar]
  4. Arora T, Mullangi S, Vadakekut ES, et al. Epithelial ovarian cancer. StatPearls. Treasure Island (FL) : StatPearls Publishing, 2025 : [Google Scholar]
  5. Tavares V, Marques IS, Melo IG de, et al. Paradigm shift: a comprehensive review of ovarian cancer management in an era of advancements. Inter J Mol Sci 2024 ; 25 : 1845. [Google Scholar]
  6. Casini A, Pöthig A. Metals in cancer research: beyond platinum metallodrugs. ACS Cent Sci 2024 ; 10 : 242–50. [Google Scholar]
  7. Mjos KD, Orvig C. Metallodrugs in medicinal inorganic chemistry. Chem Rev 2014 ; 114 : 4540–63. [Google Scholar]
  8. Wei F, Liang J, Shen X-C, et al. Recent advances in the development of metallodrugs for cancer chemoimmunotherapy. Coordi Chem Rev 2025 ; 526 : 216319. [Google Scholar]
  9. Ghosh S. Cisplatin: The first metal based anticancer drug. Bioorg Chem 2019 ; 88 : 102925. [Google Scholar]
  10. Gold JM, Raja A. Cisplatin. StatPearls. Treasure Island (FL) : StatPearls Publishing, 2025 : [Google Scholar]
  11. Tchounwou PB, Dasari S, Noubissi FK, et al. Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy. J Exp Pharmacol 2021 ; 13 : 303–28. [Google Scholar]
  12. Rossi A. Relapsed small-cell lung cancer: platinum re-challenge or not. J Thor Dis 2016 ; 8. [Google Scholar]
  13. Balfourier A, Kolosnjaj-Tabi J, Luciani N, et al. Gold-based therapy: From past to present. Proc Natl Acad Sci USA 2020 ; 117 : 22639–48. [Google Scholar]
  14. Groessl M, Reisner E, Hartinger CG, et al. Structure−activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L (S-dmso)ruthenate (III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity. J Med Chem 2007 ; 50 : 2185–93. [Google Scholar]
  15. Spratlin JL, O’Kane GM, Oh D-Y, et al. BOLD-100-001 (TRIO039): a phase 2 study of BOLD-100 in combination with FOLFOX in patients with advanced mCRC previously treated with FOLFOX/CAPOX— Efficacy and safety analysis. JCO 2024 ; 42 : 143. [Google Scholar]
  16. Jaouen G, Vessières A, Top S. Ferrocifen type anti cancer drugs. Chem Soc Rev 2015 ; 44 : 8802–17. [Google Scholar]
  17. Wang Y, Pigeon P, Li W, et al. Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells. Eur J Med Chem 2022 ; 234 : 114202. [Google Scholar]
  18. Maillet A, Yadav S, Loo YL, et al. A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma. Cell Death Dis 2013 ; 4 : e653. [Google Scholar]
  19. Dieckmann S, Riedel R, Harms K, et al. Pyridocarbazole-rhodium (III) complexes as protein kinase inhibitors. Eur J Inorg Chem 2012 ; 2012 : 813–21. [Google Scholar]
  20. Boros E, Dyson PJ, Gasser G. Classification of metal-based drugs according to their mechanisms of action. Chem 2020 ; 6 : 41–60. [Google Scholar]
  21. Adhikari S, Nath P, Das A, et al. A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies. Biomed Pharmacother 2024 ; 171 : 116211. [Google Scholar]
  22. Alessio E, Messori L. NAMI-A and KP1019/1339, Two iconic ruthenium anticancer drug candidates face-to-face: a case story in medicinal inorganic chemistry. Molecules 2019 ; 24 : 1995. [Google Scholar]
  23. Chen Q, Ramu V, Aydar Y, et al. TLD1433 Photosensitizer inhibits conjunctival melanoma cells in zebrafish ectopic and orthotopic tumour models. Cancers 2020 ; 12 : 587. [Google Scholar]
  24. Oliveira KM, Honorato J, Demidoff FC, et al. Lapachol in the design of a new ruthenium (II)- diphosphine complex as a promising anticancer metallodrug. J Inorg Biochem 2021 ; 214 : 111289. [Google Scholar]
  25. Sumithaa C, Ganeshpandian M. Half-Sandwich Ruthenium arene complexes bearing clinically approved drugs as ligands: the importance of metal-drug synergism in metallodrug design. Mol Pharm 2023 ; 20 : 1453–79. [Google Scholar]
  26. Notaro A, Frei A, Rubbiani R, et al. Ruthenium (II) complex containing a redox-active semiquinonate ligand as a potential chemotherapeutic agent: from synthesis to in vivo studies. J. Med. Chem. 2020 ; 63 : 5568–84. [Google Scholar]
  27. Beach MA, Nayanathara U, Gao Y, et al. Polymeric nanoparticles for drug delivery. Chem. Rev. 2024 ; 124 : 5505–616. [Google Scholar]
  28. Dantas KCF, Rosário J dos S, Silva-Caldeira PP. Polymeric nanosystems applied for metal-based drugs and photosensitizers delivery: the state of the art and recent advancements. Pharmaceutics 2022 ; 14 : 1506. [Google Scholar]
  29. Kumar Sahu AK, Kashyap P, Yadav R, et al. Properties and Applications of Ruthenium. In : Seehra MS, Bristow AD, eds. Noble and Precious Metals - Properties, Nanoscale Effects and Applications. Rijeka : IntechOpen, 2018. [Google Scholar]
  30. Lin K, Zhao Z-Z, Bo H-B, et al. Applications of ruthenium complex in tumor diagnosis and therapy. Front Pharmacol 2018 ; 9. [Google Scholar]
  31. Thota S, Rodrigues DA, Crans DC, et al. Ru (II) compounds: next-generation anticancer metallotherapeutics? J Med Chem 2018 ; 61 : 5805–21. [Google Scholar]
  32. Antonarakis ES, Emadi A. Ruthenium-based chemotherapeutics: are they ready for prime time? Cancer Chemother Pharmacol 2010 ; 66 : 1–9. [Google Scholar]
  33. Zeng L, Gupta P, Chen Y, et al. The development of anticancer ruthenium (ii) complexes: from single molecule compounds to nanomaterials. Chem Soc Rev 2017 ; 46 : 5771–804. [Google Scholar]
  34. Wan D, Tang B, Wang Y-J, et al. Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption. Eur J Med Chem 2017 ; 139 : 180–90. [Google Scholar]
  35. Hoye AT, Davoren JE, Wipf P, et al. Targeting mitochondria. Acc Chem Re. 2008 ; 41 : 87–97. [Google Scholar]
  36. Yousif LF, Stewart KM, Kelley SO. Targeting mitochondria with organelle-specific compounds: strategies and applications. Chembiochem 2009 ; 10 : 1939–50. [Google Scholar]
  37. Zhang W, Chen W, Fu F, et al. Mitochondria-targeted ruthenium (II) complexes for photodynamic therapy and GSH detection in living cells. Dalton Trans 2024 ; 53 : 5957–65. [Google Scholar]
  38. Brabec V, Nováková O. DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat 2006 ; 9 : 111–22. [Google Scholar]
  39. Bruce MI, Costuas K, Davin T, et al. Iron versus ruthenium: dramatic changes in electronic structure result from replacement of one fe by ru in [{Cp*(dppe)Fe}-CC-CC-{Fe (dppe)Cp*}]n + (n = 0, 1, 2). Organometallics 2005 ; 24 : 3864–81. [Google Scholar]
  40. Gatter KC, Brown G, Trowbridge IS, et al. Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol 1983 ; 36 : 539–45. [Google Scholar]
  41. Notaro A, Jakubaszek M, Rotthowe N, et al. Increasing the cytotoxicity of ru (ii) polypyridyl complexes by tuning the electronic structure of dioxo ligands. J Am Chem Soc 2020 ; 142 : 6066–84. [Google Scholar]
  42. Handbook of Pharmaceutical Excipients – 7th Edition Pharmaceutical Development and Technology 2013 ; 18 : 544. [Google Scholar]
  43. Schwartzberg LS, Navari RM. Safety of polysorbate 80 in the oncology setting. Adv Ther 2018 ; 35 : 754–67. [Google Scholar]
  44. Sung YK, Kim SW. Recent advances in polymeric drug delivery systems. Biomater Res 2020 ; 24 : 12. [Google Scholar]
  45. Elumalai K, Srinivasan S, Shanmugam A. Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment. Biomed Tech 2024 ; 5 : 109–22. [Google Scholar]
  46. Idrees H, Zaidi SZJ, Sabir A, et al. A review of biodegradable natural polymer-based nanoparticles for drug delivery applications. Nanomaterials (Basel) 2020 ; 10 : 1970. [Google Scholar]
  47. Redrado M, Xiao Z, Upitak K, et al. Applications of biodegradable polymers in the encapsulation of anticancer metal complexes. Adv Funct Mater 2024 ; 34 : 2401950. [Google Scholar]
  48. Klojdová I, Milota T, Smetanová J, et al. Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds? Pharmaceutic 2023 ; 16 : 362. [Google Scholar]
  49. Villemin E, Ong YC, Thomas CM, et al. Polymer encapsulation of ruthenium complexes for biological and medicinal applications. Nat Rev Chem 2019 ; 3 : 261–82. [Google Scholar]
  50. Karges J. Encapsulation of Ru (II) Polypyridine complexes for tumor-targeted anticancer therapy. BME Frontiers 2023 ; 4 : 0024. [Google Scholar]
  51. António JPM, Gandioso A, Nemati F, et al. Polymeric encapsulation of a ruthenium (II) polypyridyl complex: from synthesis to in vivo studies against high-grade epithelial ovarian cancer. Chem Sci 2023 ; 14 : 362–71. [Google Scholar]
  52. Soliman N, McKenzie LK, Karges J, et al. Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer. Chem Sci 2020 ; 11 : 2657–63. [Google Scholar]
  53. Soliman N, Sol V, Ouk T-S, et al. Encapsulation of a Ru (II) polypyridyl complex into polylactide nanoparticles for antimicrobial photodynamic therapy. Pharmaceutics 2020 ; 12 : 961. [Google Scholar]

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