Open Access
Issue
Med Sci (Paris)
Volume 38, Number 12, Décembre 2022
Un monde de virus
Page(s) 1068 - 1071
Section Nouvelles
DOI https://doi.org/10.1051/medsci/2022157
Published online 13 December 2022
  1. Triebel F, Jitsukawa S, Baixeras Eet al. Lag-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med 1990 ; 171 : 1393–1405. [CrossRef] [PubMed] [Google Scholar]
  2. Huard B, Tournier M, Hercend Tet al. Lymphocyte-activation gene 3 / major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol 1994 ; 24 : 3216–3221. [CrossRef] [PubMed] [Google Scholar]
  3. Andrews LP, Yano H, Vignali DAA. Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups. Nat Immunol 2019 ; 20 : 1425–1434. [Google Scholar]
  4. Maruhashi T, Sugiura D, Okazaki I M, Okazaki T. LAG-3: from molecular functions to clinical applications. JITC 2020; 8 : e001014. [Google Scholar]
  5. Guy C, Mitrea DM, Chou P-C, et al. LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation. Nat Immunol 2022; 23 : 757–67. [Google Scholar]
  6. Maruhashi T, Okasaki I-M, Sugiura Det al. LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII. Nat Immunol 2018 ; 19 : 1415–1426. [Google Scholar]
  7. Workman CJ, Dugger KJ, Vignali DAA. Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J Immunol 2002 ; 169 : 5392–5395. [CrossRef] [PubMed] [Google Scholar]
  8. Maeda TK, Sugiura D, Okasaki I-Met al. Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation. J Biol Chem 2019 ; 294 : 6017–6026. [CrossRef] [PubMed] [Google Scholar]
  9. Li L, Guo X, Shi Xet al. Ionic CD3−Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci USA 2017 ; 114 : E5891–E5899. [Google Scholar]
  10. Lin RS, Rodriguez C, Veillette A, Lodish HF. Zinc is essential for binding of p56 lck to CD4 and CD8. J Biol Chem 1998 ; 273 : 32878–32882. [CrossRef] [PubMed] [Google Scholar]
  11. Bae J, Lee SJ, Park C-Get al. Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling. J Immunol 2014 ; 193 : 3101–3112. [CrossRef] [PubMed] [Google Scholar]
  12. Lythgoe MP, Liu DSK, Annels NE, et al. Gene of the month: Lymphocyte-activation gene 3 (LAG-3). J Clin Pathol 2021; 74 : 543–7. [CrossRef] [PubMed] [Google Scholar]
  13. Hivroz C. LAG3 disrupts the TCR signal by local acidification. Nat Immunol 2019 ; 23 : 649–651. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.