Free Access
Issue
Med Sci (Paris)
Volume 35, Number 11, Novembre 2019
Page(s) 834 - 836
Section Le Magazine
DOI https://doi.org/10.1051/medsci/2019165
Published online 17 December 2019
  1. Tabrizi S, Leavitt B, Landwehrmeyer B, et al. Targeting huntingtin expression in patients with Huntington’s disease. N Engl J Med 2019 ; 380 : 2307–16. [Google Scholar]
  2. Mariani LL, Tesson C, Charles P, et al. Expanding the spectrum of genes involved in Huntington disease using a combined clinical and genetic approach. JAMA Neurol 2016 ; 73 : 1105–14. [Google Scholar]
  3. Cazeneuve C, Durr A. Huntington’s disease: genetic and molecular studies. In: Bates G, Tabrizi S, Jones L, eds. Huntington’s disease. Oxford : Oxford University Press, 2014 : p. 109–31. [Google Scholar]
  4. Zuccato C, Valenza M, Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington’s disease. Physiol Rev 2010 ; 90 : 905–81. [Google Scholar]
  5. Clabough EB, Zeitlin SO. Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington’s disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Hum Mol Genet 2006 ; 15 : 607–23. [CrossRef] [PubMed] [Google Scholar]
  6. Zheng S, Clabough EB, Sarkar S, et al. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet 2010 ; 6 : e1000838. [CrossRef] [PubMed] [Google Scholar]
  7. Darnell G, Orgel JP, Pahl R, Meredith SC. Flanking polyproline sequences inhibit β-sheet structure in polyglutamine segments by inducing PPII-like helix structure. J Mol Biol 2007 ; 374 : 688–704. [Google Scholar]
  8. Saudou F, Humbert S. The biology of huntingtin. Neuron 2016 ; 89 : 910–26. [CrossRef] [PubMed] [Google Scholar]
  9. Thion MS, Tézenas du Montcel S, Golmard JL, et al. CAG repeat size in huntingtin alleles is associated with cancer prognosis. Eur J Hum Genet 2016 ; 24 : 1310–5. [Google Scholar]
  10. Coarelli G, Diallo A, Thion MS, et al. Low cancer prevalence in polyglutamine expansion diseases. Neurology. 2017 ; 88 : 1114–9. [Google Scholar]
  11. Barnat M, Le Friec J, Benstaali C, Humbert S. Huntingtin-mediated multipolar-bipolar transition of newborn cortical neurons is critical for their postnatal neuronal morphology. Neuron 2017 ; 93 : 99–114. [CrossRef] [PubMed] [Google Scholar]

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