Free Access
Med Sci (Paris)
Volume 29, Number 10, Octobre 2013
Page(s) 855 - 860
Section M/S Revues
Published online 18 October 2013
  1. Wang C, Wu H, Katritch V, et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature 2013 ; 497 : 338–343. [CrossRef] [PubMed] [Google Scholar]
  2. Ruat M, Angot E, Traiffort E. Sonic Hedgehog, un morphogène en quête de fonction dans le cerveau adulte. Med Sci (Paris) 2011 ; 27 : 979–985. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  3. Ruat M, Roudaut H, Ferent J, Traiffort E. Hedgehog trafficking, cilia and brain functions. Differentiation 2012 ; 83 : S97–104. [CrossRef] [PubMed] [Google Scholar]
  4. Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009 ; 30 : 303–312. [CrossRef] [PubMed] [Google Scholar]
  5. Ng JM, Curran T. The Hedgehog’s tale: developing strategies for targeting cancer. Nat Rev Cancer 2011 ; 11 : 493–501. [CrossRef] [PubMed] [Google Scholar]
  6. Lin TL, Matsui W. Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco Targets Ther 2012 ; 5 : 47–58. [CrossRef] [PubMed] [Google Scholar]
  7. Bourdeaut F, Pouponnot C, Ayrault O. Les médulloblastomes et leurs cellules d’origine. Med Sci (Paris) 2012 ; 28 : 805–809. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  8. Queiroz KC, Spek CA, Peppelenbosch MP. Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors. Drug Resist Updat 2012 ; 15 : 211–222. [CrossRef] [PubMed] [Google Scholar]
  9. Hadden MK. Hedgehog pathway inhibitors: a patent review (2009-present). Expert Opin Ther Pat 2013 ; 23 : 345–361. [CrossRef] [PubMed] [Google Scholar]
  10. Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009 ; 326 : 572–574. [CrossRef] [PubMed] [Google Scholar]
  11. Buonamici S, Williams J, Morrissey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010 ; 2 : 51–70. [CrossRef] [Google Scholar]
  12. Bender M, Hipsking P, Capen A, et al. Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling Cancer Res 2011 ; 71 : 2819. [CrossRef] [Google Scholar]
  13. Roudaut H, Traiffort E, Gorojankina T, et al. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol 2011 ; 79 : 453–460. [CrossRef] [PubMed] [Google Scholar]
  14. Schulte G. International union of basic and clinical pharmacology. LXXX. The class Frizzled receptors. Pharmacol Rev 2010 ; 62 : 632–667. [CrossRef] [PubMed] [Google Scholar]
  15. Riobo NA, Lu K, Ai X, et al. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci USA 2006 ; 103 : 4505–4510. [CrossRef] [PubMed] [Google Scholar]
  16. Masdeu C, Faure H, Coulombe J, et al. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochem Biophys Res Commun 2006 ; 349 : 471–479. [CrossRef] [PubMed] [Google Scholar]
  17. Banères JL, Mouillac B. Manipulation des récepteurs couplés aux protéines G : expression, purification et stabilisation in vitro. Med Sci (Paris) 2012 ; 28 : 837–844. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  18. Nehme R, Joubert O, Bidet M, et al. Stability study of the human G-protein coupled receptor, Smoothened. Biochim Biophys Acta 2010 ; 1798 : 1100–1110. [CrossRef] [PubMed] [Google Scholar]
  19. Wang C, Jiang Y, Ma J, et al. Structural basis for molecular recognition at serotonin receptors. Science 2013 ; 340 : 610–614. [CrossRef] [PubMed] [Google Scholar]
  20. Wacker D, Wang C, Katritch V, et al. Structural features for functional selectivity at serotonin receptors. Science 2013 ; 340 : 615–619. [CrossRef] [PubMed] [Google Scholar]
  21. Granier S. Structure des récepteurs mu et delta des opiacés. Med Sci (Paris) 2012 ; 28 : 870–875. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  22. Chen Y, Jiang J. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res 2013 ; 23 : 186–200. [CrossRef] [PubMed] [Google Scholar]
  23. Ruat M, Petrel C. Comment moduler l’activité du récepteur du calcium extracellulaire ? Med Sci (Paris) 2004 ; 20 : 980–985. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  24. Kniazeff J, Pin JP., Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ? Le récepteur GABAB sous interrogatoire. Med Sci (Paris) 2012 ; 28 : 858–863. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  25. Zhao Y, Tong C, Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007 ; 450 : 252–258. [CrossRef] [PubMed] [Google Scholar]
  26. Shi D, Lv X, Zhang Z, et al. Smoothened oligomerization/higher order clustering in lipid rafts is essential for high hedgehog activity transduction. J Biol Chem 2013 ; 288 : 12605–12614. [CrossRef] [PubMed] [Google Scholar]
  27. Dijkgraaf GJ, Alicke B, Weinmann L, et al. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 2011 ; 71 : 435–444. [CrossRef] [PubMed] [Google Scholar]
  28. Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 2010 ; 17 : 388–399. [CrossRef] [PubMed] [Google Scholar]
  29. Gorojankina T, Hoch L, Faure H, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol 2013 ; 83 : 1020–1029. [CrossRef] [PubMed] [Google Scholar]
  30. Teperino R, Amann S, Bayer M, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 2012 ; 151 : 414–426. [CrossRef] [PubMed] [Google Scholar]
  31. Horn A, Palumbo K, Cordazzo C, et al. Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum 2012 ; 64 : 2724–2733. [CrossRef] [PubMed] [Google Scholar]
  32. Lin AC, Seeto BL, Bartoszko JM, et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 2009 ; 15 : 1421–1425. [CrossRef] [PubMed] [Google Scholar]
  33. Nachtergaele S, Mydock LK, Krishnan K, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol 2012 ; 8 : 211–220. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.