Accès gratuit
Numéro
Med Sci (Paris)
Volume 29, Numéro 10, Octobre 2013
Page(s) 855 - 860
Section M/S Revues
DOI https://doi.org/10.1051/medsci/20132910012
Publié en ligne 18 octobre 2013
  1. Wang C, Wu H, Katritch V, et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature 2013 ; 497 : 338–343. [CrossRef] [PubMed]
  2. Ruat M, Angot E, Traiffort E. Sonic Hedgehog, un morphogène en quête de fonction dans le cerveau adulte. Med Sci (Paris) 2011 ; 27 : 979–985. [CrossRef] [EDP Sciences] [PubMed]
  3. Ruat M, Roudaut H, Ferent J, Traiffort E. Hedgehog trafficking, cilia and brain functions. Differentiation 2012 ; 83 : S97–104. [CrossRef] [PubMed]
  4. Scales SJ, de Sauvage FJ. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009 ; 30 : 303–312. [CrossRef] [PubMed]
  5. Ng JM, Curran T. The Hedgehog’s tale: developing strategies for targeting cancer. Nat Rev Cancer 2011 ; 11 : 493–501. [CrossRef] [PubMed]
  6. Lin TL, Matsui W. Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco Targets Ther 2012 ; 5 : 47–58. [CrossRef] [PubMed]
  7. Bourdeaut F, Pouponnot C, Ayrault O. Les médulloblastomes et leurs cellules d’origine. Med Sci (Paris) 2012 ; 28 : 805–809. [CrossRef] [EDP Sciences] [PubMed]
  8. Queiroz KC, Spek CA, Peppelenbosch MP. Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors. Drug Resist Updat 2012 ; 15 : 211–222. [CrossRef] [PubMed]
  9. Hadden MK. Hedgehog pathway inhibitors: a patent review (2009-present). Expert Opin Ther Pat 2013 ; 23 : 345–361. [CrossRef] [PubMed]
  10. Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009 ; 326 : 572–574. [CrossRef] [PubMed]
  11. Buonamici S, Williams J, Morrissey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010 ; 2 : 51–70. [CrossRef]
  12. Bender M, Hipsking P, Capen A, et al. Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling Cancer Res 2011 ; 71 : 2819. [CrossRef]
  13. Roudaut H, Traiffort E, Gorojankina T, et al. Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol 2011 ; 79 : 453–460. [CrossRef] [PubMed]
  14. Schulte G. International union of basic and clinical pharmacology. LXXX. The class Frizzled receptors. Pharmacol Rev 2010 ; 62 : 632–667. [CrossRef] [PubMed]
  15. Riobo NA, Lu K, Ai X, et al. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci USA 2006 ; 103 : 4505–4510. [CrossRef]
  16. Masdeu C, Faure H, Coulombe J, et al. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochem Biophys Res Commun 2006 ; 349 : 471–479. [CrossRef] [PubMed]
  17. Banères JL, Mouillac B. Manipulation des récepteurs couplés aux protéines G : expression, purification et stabilisation in vitro. Med Sci (Paris) 2012 ; 28 : 837–844. [CrossRef] [EDP Sciences] [PubMed]
  18. Nehme R, Joubert O, Bidet M, et al. Stability study of the human G-protein coupled receptor, Smoothened. Biochim Biophys Acta 2010 ; 1798 : 1100–1110. [CrossRef] [PubMed]
  19. Wang C, Jiang Y, Ma J, et al. Structural basis for molecular recognition at serotonin receptors. Science 2013 ; 340 : 610–614. [CrossRef] [PubMed]
  20. Wacker D, Wang C, Katritch V, et al. Structural features for functional selectivity at serotonin receptors. Science 2013 ; 340 : 615–619. [CrossRef] [PubMed]
  21. Granier S. Structure des récepteurs mu et delta des opiacés. Med Sci (Paris) 2012 ; 28 : 870–875. [CrossRef] [EDP Sciences] [PubMed]
  22. Chen Y, Jiang J. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res 2013 ; 23 : 186–200. [CrossRef] [PubMed]
  23. Ruat M, Petrel C. Comment moduler l’activité du récepteur du calcium extracellulaire ? Med Sci (Paris) 2004 ; 20 : 980–985. [CrossRef] [EDP Sciences] [PubMed]
  24. Kniazeff J, Pin JP., Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ? Le récepteur GABAB sous interrogatoire. Med Sci (Paris) 2012 ; 28 : 858–863. [CrossRef] [EDP Sciences] [PubMed]
  25. Zhao Y, Tong C, Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007 ; 450 : 252–258. [CrossRef] [PubMed]
  26. Shi D, Lv X, Zhang Z, et al. Smoothened oligomerization/higher order clustering in lipid rafts is essential for high hedgehog activity transduction. J Biol Chem 2013 ; 288 : 12605–12614. [CrossRef] [PubMed]
  27. Dijkgraaf GJ, Alicke B, Weinmann L, et al. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 2011 ; 71 : 435–444. [CrossRef] [PubMed]
  28. Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 2010 ; 17 : 388–399. [CrossRef] [PubMed]
  29. Gorojankina T, Hoch L, Faure H, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol 2013 ; 83 : 1020–1029. [CrossRef] [PubMed]
  30. Teperino R, Amann S, Bayer M, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 2012 ; 151 : 414–426. [CrossRef] [PubMed]
  31. Horn A, Palumbo K, Cordazzo C, et al. Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum 2012 ; 64 : 2724–2733. [CrossRef] [PubMed]
  32. Lin AC, Seeto BL, Bartoszko JM, et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med 2009 ; 15 : 1421–1425. [CrossRef] [PubMed]
  33. Nachtergaele S, Mydock LK, Krishnan K, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol 2012 ; 8 : 211–220. [CrossRef] [PubMed]

Les statistiques affichées correspondent au cumul d'une part des vues des résumés de l'article et d'autre part des vues et téléchargements de l'article plein-texte (PDF, Full-HTML, ePub... selon les formats disponibles) sur la platefome Vision4Press.

Les statistiques sont disponibles avec un délai de 48 à 96 heures et sont mises à jour quotidiennement en semaine.

Le chargement des statistiques peut être long.