Free Access
Issue
Med Sci (Paris)
Volume 26, Number 2, Février 2010
Page(s) 177 - 184
Section M/S revues
DOI https://doi.org/10.1051/medsci/2010262177
Published online 15 February 2010
  1. Andrews DL, Beames B, Summers MD, Park W. Characterization of the lipid acyl hydrolase activity of the major potato (Solanum tuberosum) tuber protein, patatin, by cloning and abundant expression in a baculovirus vector. Biochem J 1988; 252 : 199–206. [Google Scholar]
  2. Racusen D. Lipid acyl hydrolase of patatin. Can J Bot 1984; 62 : 1640–4. [Google Scholar]
  3. Senda K, Yoshioka H, Doke N, Kawakita K. A cytosolic phospholipase A2 from potato tissues appears to be patatin. Plant Cell Physiol 1996; 37 : 347–53. [Google Scholar]
  4. Dhondt S, Geoffroy P, Stelmach BA, et al. Soluble phospholipase A2 activity is induced before oxylipin accumulation in tobacco mosaic virus-infected tobacco leaves and is contributed by patatin-like enzymes. Plant J 2000; 23 : 431–40. [Google Scholar]
  5. Hirschberg HJ, Simons JW, Dekker N, Egmond MR. Cloning, expression, purification and characterization of patatin, a novel phospholipase A. Eur J Biochem 2001; 268 : 5037–44. [Google Scholar]
  6. Rydel TJ, Williams JM, Krieger E, et al. The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad. Biochemistry 2003; 42 : 6696–708. [Google Scholar]
  7. Smirnova E, Goldberg EB, Makarova KS, et al. ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells. EMBO Rep 2006; 7: 106–13. [Google Scholar]
  8. Schaloske RH, Dennis EA. The phospholipase A2 superfamily and its group numbering system. Biochim Biophys Acta 2006; 1761 : 1246–59. [Google Scholar]
  9. Jenkins CM, Mancuso DJ, Yan W, et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279 : 48968–75. [Google Scholar]
  10. Kienesberger PC, Oberer M, Lass A, Zechner R. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res 2009; 50 : S63–8. [Google Scholar]
  11. Lio YC, Dennis EA. Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta 1998; 1392 : 320–32. [Google Scholar]
  12. Yan W, Jenkins CM, Han X, et al. The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling. J Biol Chem 2005; 280 : 26669–79. [Google Scholar]
  13. Ma Z, Turk J. The molecular biology of the group VIA Ca2+-independent phospholipase A2. Prog Nucleic Acid Res Mol Biol 2001; 67 : 1–33. [Google Scholar]
  14. Turk J, Ramanadham S. The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells. Can J Physiol Pharmacol 2004; 82 : 824–32. [Google Scholar]
  15. Bao S, Miller DJ, Ma Z, et al. Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. J Biol Chem 2004; 279 : 38194–200. [Google Scholar]
  16. Bao S, Jacobson DA, Wohltmann M, et al. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. Am J Physiol Endocrinol Metab 2008; 294 : E217–29. [Google Scholar]
  17. Ramanadham S, Yarasheski KE, Silva MJ, et al. Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice. Am J Pathol 2008; 172 : 868–81. [Google Scholar]
  18. Malik I, Turk J, Mancuso DJ, et al. Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Am J Pathol 2008; 172 : 406–16. [Google Scholar]
  19. Gregory A, Westaway SK, Holm IE, et al. Neurodegeneration associated with genetic defects in phospholipase A(2). Neurology 2008; 71 : 1402–9. [Google Scholar]
  20. Mancuso DJ, Jenkins CM, Gross RW. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). J Biol Chem 2000; 275 : 9937–45. [Google Scholar]
  21. Mancuso DJ, Sims HF, Han X, et al. Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem 2007; 282 : 34611–22. [Google Scholar]
  22. Mancuso DJ, Han X, Jenkins CM,et al. Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem 2007; 282 : 9216–27. [Google Scholar]
  23. Winrow CJ, Hemming ML, Allen DM, et al. Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Nat Genet 2003; 33 : 477–85. [Google Scholar]
  24. Van Tienhoven M, Atkins J, Li Y, Glynn P. Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem 2002; 277 : 20942–8. [Google Scholar]
  25. Akassoglou K, Malester B, Xu J, et al. Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci USA 2004; 101 : 5075–80. [Google Scholar]
  26. Rainier S, Bui M, Mark E, et al. Neuropathy target esterase gene mutations cause motor neuron disease. Am J Hum Genet 2008; 82 : 780–5. [Google Scholar]
  27. Kienesberger PC, Lass A, Preiss-Landl K, et al. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. J Biol Chem 2008; 283 : 5908–17. [Google Scholar]
  28. Wilson PA, Gardner SD, Lambie NM, et al. Characterization of the human patatin-like phospholipase family. J Lipid Res 2006; 47 : 1940–9. [Google Scholar]
  29. Lake AC, Sun Y, Li JL, et al. Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. J Lipid Res 2005; 46 : 2477–87. [Google Scholar]
  30. Gao JG, Simon M. A comparative study of human GS2, its paralogues, and its rat orthologue. Biochem Biophys Res Commun 2007; 360 : 501–6. [Google Scholar]
  31. Baulande S, Lasnier F, Lucas M, Pairault J. Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. J Biol Chem 2001; 276 : 33336–44. [Google Scholar]
  32. Moldes M, Beauregard G, Faraj M, et al. Adiponutrin gene is regulated by insulin and glucose in human adipose tissue. Eur J Endocrinol 2006; 155 : 461–8. [Google Scholar]
  33. Kershaw EE, Hamm JK, Verhagen LA, et al. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes 2006; 55 : 148–57. [Google Scholar]
  34. Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40 : 1461–5. [Google Scholar]
  35. Yuan X, Waterworth D, Perry JR, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet 2008; 83 : 520–8. [Google Scholar]
  36. Baulande S. Polymorphisms in adiponutrin gene and association to hepatic steatosis. Med Sci (Paris) 2009; 25 : 130–2. [Google Scholar]
  37. Kotronen A, Johansson LE, Johansson LM, et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009; 52 : 1056–60. [Google Scholar]
  38. Zimmermann R, Strauss JG, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004; 306 : 1383–6. [Google Scholar]
  39. Villena JA, Roy S, Sarkadi-Nagy E, et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 2004; 279 : 47066–75. [Google Scholar]
  40. Kim JY, Tillison K, Lee JH, et al. The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma. Am J Physiol Endocrinol Metab 2006; 291 : E115–27. [Google Scholar]
  41. Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006; 312 : 734–7. [Google Scholar]
  42. Fischer J, Lefèvre C, Morava E, et al. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet 2007; 39 : 28–30. [Google Scholar]
  43. Fischer J, Negre-Salvayre A, Salvayre R. Neutral lipid storage diseases and ATGL (adipose triglyceride lipase) and CGI-58/ABHD5 (alpha-beta hydrolase domain-containing 5) deficiency: myopathy, ichthyosis, but no obesity. Med Sci (Paris) 2007; 23 : 575–8. [Google Scholar]
  44. Schoenborn V, Heid IM, Vollmert C, et al. The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 2006; 55 : 1270–5. [Google Scholar]
  45. Heitz T. Les multiples fonctions des protéines lipolytiques à domaine patatine. Med Sci (Paris) 2010; 26 : 128–9. [Google Scholar]

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