Free Access
Med Sci (Paris)
Volume 23, Number 10, Octobre 2007
Page(s) 885 - 894
Section Recherche et partenariat
Published online 15 October 2007
  1. Himsworth HP. Diabetes mellitus : its differentiation into insulin sensitive and insulin insensitive types. Lancet 1936; I : 1117–22. [Google Scholar]
  2. Yalow RS, Berson SA. Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic. Diabetes 1960; 9 : 254–60. [Google Scholar]
  3. Efendic S, Luft R, Wajngot A. Aspects of the pathogenesis of type 2 diabetes. Endocrinol Rev 1984; 5 : 395–410. [Google Scholar]
  4. Nesher R, Della Casa L, Litvin, et al. Insulin deficiency and insulin resistance in type 2 (non-insulin-dependent) diabetes : quantitative contributions of pancreatic and peripheral responses to glucose homeostasis. Eur J Clin Invest 1987; 17 : 266–74. [Google Scholar]
  5. Ilkova H, Glaser B, Tunçkale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care 1997; 20 : 1353–6. [Google Scholar]
  6. Kruszynka YT, Home PD, Hanning I, Alberti KGMM. Basal and 24-h C-peptide and insulin secretion rate in normal man. Diabetologia 1987; 30 : 16–21. [Google Scholar]
  7. Ahrén B, Thorsson O. Increased insulin sensitivity is associated with reduced insulin and glucagon secretion and increased insulin clearance in man. J Clin Endocrinol Metab 2003; 88 : 1264–70. [Google Scholar]
  8. Luft R, Cerasi E, Hamberger CA. Studies on the pathogenesis of diabetes in acromegaly. Acta Endocr (Kbh) 1967; 56 : 593–607. [Google Scholar]
  9. Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy : increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 1992; 130 : 1459–66. [Google Scholar]
  10. Edström K, Cerasi E, Luft R. Insulin response to glucose infusion during pregnancy. A prospective study of high and low insulin responders with normal carbohydrate tolerance. Acta Endocr (Kbh) 1974; 75 : 87–104. [Google Scholar]
  11. Bouwens L, Rooman I. Regulation of Pancreatic β-cell mass. Physiol Rev 2005; 85 : 1255–70. [Google Scholar]
  12. Sorenson R, Brelje T. Adaptation of islets of Langerhans to pregnancy : β cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 1997; 29 : 301–7. [Google Scholar]
  13. Klöppel G, Löhr M, Habich K, et al. Islet pathology and pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Path Res 1985; 4 : 110–25. [Google Scholar]
  14. Butler AE, Janson J, Bonner-Weir S, et al. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52 : 102–10. [Google Scholar]
  15. Cerasi E, Luft R. Plasma insulin response to sustained hyperglycaemia induced by glucose infusion in human subjects. Lancet 1963; 282 : 1359–61. [Google Scholar]
  16. Cerasi E, Luft R. What is inherited — what is added. Hypothesis for the pathogenesis of diabetes mellitus. Diabetes 1967; 16 : 615–27. [Google Scholar]
  17. Alvarsson M, Wajngot A, Cerasi E, Efendic S. K-value and low insulin secretion in a non-obese white population predicted glucose tolerance after 25 years. Diabetologia 2005; 48 : 2262–8. [Google Scholar]
  18. Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia 2001; 44 : 929–45. [Google Scholar]
  19. Deng S, Vatamaniuk M, Huang M, et al. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 2004; 53 : 624–32. [Google Scholar]
  20. Kaiser N, Yuli M, Üçkaya C, et al. Dynamic changes in beta-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in Psammomys obesus. Impact of glycemic control. Diabetes 2005; 54 : 138–45. [Google Scholar]
  21. Kaiser N, Nesher R, Donath MY, et al. Psammomys Obesus, a model for environment-gene interactions in type 2 diabetes. Diabetes 2005; 54 (suppl 2) : S137–44. [Google Scholar]
  22. Rahier J, Guiot Y, Sempoux C. Diabète de type 2 et déficit des cellules B. In : Selam JL, ed. Journées annuelles de diabétologie de l’Hôtel-Dieu. Paris : Flammarion Médecine-Sciences, 2004 : 15–20. [Google Scholar]
  23. Bernard-Kargar C, Ktorza A. Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes 2001; 50 (suppl 1) : S30–5. [Google Scholar]
  24. Bernard C, Thibault C, Berthault, et al. Pancreatic β-cell regeneration after 48h glucose infusion in mildly diabetic rats is not correlated with functional improvement. Diabetes 1998; 47 : 1058–65. [Google Scholar]
  25. Frederici M, Hribal M, Perego L, et al. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans : a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 2001; 50 : 1290–301. [Google Scholar]
  26. Maedler K, Sergeev P, Ris F, et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110 : 851–60. [Google Scholar]
  27. Koyama M, Wada R, Sakuraba H, et al. Accelerated loss of islet β-cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 1998; 153 : 537–45. [Google Scholar]
  28. McGarry J, Dobbins R. Fatty acids, lipotoxicity and insulin secretion. Diabetologia 1999; 42 : 128–38. [Google Scholar]
  29. Lee Y, Hirose H, Ohneda M, et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats : impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 1994; 91 : 10878–82. [Google Scholar]
  30. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced β-cell apoptosis : a link between obesity and diabetes. Proc Natl Acad Sci USA 1998; 95 : 2498–502. [Google Scholar]
  31. Shimabukuro M, Higa M, Zhou Y, et al. Lipoapoptosis in β-cells of obese prediabetic fa/fa rats. J Biol Chem 1998; 273 : 32487–90. [Google Scholar]
  32. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet β-cells in diabetes. J Biol Chem 2004; 279 : 42351–4. [Google Scholar]
  33. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signalling pathways mediators of insulin resistance and beta cell dysfunction ? Diabetes 2003; 52 : 1–8. [Google Scholar]
  34. Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets : evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002; 51 : 1437–42. [Google Scholar]
  35. Piro S, Anello M, Di Pietro C, et al. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets : possible role of oxidative stress. Metabolism 2002; 51 : 1340–7. [Google Scholar]
  36. Laybutt DR, Preston AM, Akerfeldt MC, et al. Endoplasmic reticulum stress contributes to beta-cell apoptosis in type 2 diabetes. Diabetologia 2007; 50 : 752–63. [Google Scholar]
  37. Cerasi E. Differential actions of glucose on insulin release : reevaluation of a mathematical model. In : Cobelli C, Bergman RN, eds. Carbohydrate metabolism. Chichester : John Wiley and Sons, 1981 : 3–22. [Google Scholar]
  38. Scott LJ, Mohlke KL, Bonnycastel LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316 : 1341–5. [Google Scholar]
  39. Saxena R, Voigt BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316 : 1331–6. [Google Scholar]
  40. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316 : 1336–41. [Google Scholar]
  41. Cauchi S, El Achhab Y, Choquet H, et al. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups : a global meta-analysis. J Mol Med 2007; 85 : 777–82. [Google Scholar]
  42. Saxena R, Gianniny L, Burtt NP, et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 2006; 55 : 2890–95. [Google Scholar]
  43. Campbell IW, Mariz S. β-cell preservation with thiazolidinediones. Diabetes Res Clin Practice 2007; 76 : 163–76. [Google Scholar]
  44. Zeender E, Maedler K, Bosco D, et al. Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta. J Clin Endocrinol Metab 2004; 89 : 5059–66. [Google Scholar]
  45. Dubois M, Pattou F, Kerr-Conte J, et al. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells. Diabetologia 2000; 43 : 1165–9. [Google Scholar]
  46. Wong VSC, Brubaker PL. From cradle to grave : pancreatic β-cell mass and glucagons-like peptide-1. Minerva Endocrinol 2006; 31 : 107–24. [Google Scholar]
  47. Edvell A, Lindstrom P. Initiation of increased pancreatic islet growth in young normoglycemic mice (umea +/?). Endocrinology 1999; 140 : 778–83. [Google Scholar]
  48. Farilla L, Hui H, Bertolotto C, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 2002; 143 : 4397–408. [Google Scholar]
  49. Movassat J, Beattie GM, Lopez AD, Hayek A. Exendin 4 up-regulates expression of pdx 1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocrinol Metab 2002; 87 : 4775–81. [Google Scholar]
  50. Combettes M, Ilic C, Broux O, et al. S40010, a potent Dpp-iv inhibitor, improves long-term glycemic control in db/db mice and increases pancreatic β-cell mass and neogenesis. Diabetes 2007; 56 (suppl 1) : A158. [Google Scholar]
  51. Efendic S, Cerasi E, Elander I, et al. Studies on low insulin responders. Acta Endocrinol 1979; 90 (suppl 224) : 5–32. [Google Scholar]
  52. Cerasi E, Luft R, Efendic S. Decreased sensitivity of the pancreatic beta-cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study. Diabetes 1972; 21 : 224–34. [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.