Free Access
Issue
Med Sci (Paris)
Volume 19, Number 10, Octobre 2003
Page(s) 931 - 936
Section M/S Revues
DOI https://doi.org/10.1051/medsci/20031910931
Published online 15 October 2003
  1. Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286: 487–91. [Google Scholar]
  2. Tukey RH, Strassburg CP. Genetic multiplicity of the human UDPglucuronosyltransferases and regulation in the gastrointestinal tract. Mol Phamacol 2001; 59: 405–14. [Google Scholar]
  3. Lévesque E, Turgeon D, Carrier JS, Montminy V, Beaulieu M, Bélanger A. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDPglucuonosyltransferase. Biochemistry 2001; 40: 3869–81. [Google Scholar]
  4. Radominska-Pandya A, Czernik PJ, Little JM, Battaglia E, Mackenzie PI. Structural and functional studies of UDPglucuronosyltransferases. Drug Metab Rev 1999; 31: 817–99. [Google Scholar]
  5. Labrie F, Luu-The V, Labrie C, et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocrinol Rev 2003; 24: 152–82. [Google Scholar]
  6. Bélanger A, Brochu M, Cliche J. Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer. J Clin Endocrinol Metab 1986; 62: 812–5. [Google Scholar]
  7. Brochu M, Bélanger A, Tremblay RR. Plasma levels of C-19 steroids and 5 alpha-reduced steroid glucuronides in hyperandrogenic and idiopathic hirsute women. Fertil Steril 1987; 48: 948–53. [Google Scholar]
  8. Green MD, Tephly TR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Disp 1996; 24: 356–63. [Google Scholar]
  9. Albert C, Vallée M, Beaudry G, Bélanger A, Hum DW. The monkey and human uridine diphosphateglucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen conjugating enzymes. Endocrinology 1999; 140: 3292–302. [Google Scholar]
  10. Beaulieu M, Lévesque E, Hum DW, Bélanger A. Isolation and characterization of a human orphan UDPglucuronosyltransferase, UGT2B11. Biochem Biophys Res Commun 1998; 248: 44–50. [Google Scholar]
  11. Carrier JS, Turgeon D, Journeault K, Hum DW, Bélanger A. Isolation and characterization of the human UGT2B7 gene. Biochem Biophys Res Commun 2000; 272: 616–21. [Google Scholar]
  12. Turgeon D, Carrier JS, Lévesque É, Hum DW, Bélanger A. Relative enzymatic activity, protein stability and tissue distribution of human steroid metabolizing UGT2B subfamily members. Endocrinology 2001; 142: 778–87. [Google Scholar]
  13. Radominska-Pandya A, Little JM, Czernik PJ. Human UDPglucuronosyltransferase 2B7. Curr Drug Metab 2001; 2: 283–98. [Google Scholar]
  14. Gestl SA, Green MD, Shearer DA, Frauenhoffer E, Tephly TR, Weisz J. Expression of UGT2B7, a UDPglucuronosyltransferase implicated in the metabolism of 4- hydroxyestrone and alltrans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers. Am J Pathol 2002; 160: 1467–79. [Google Scholar]
  15. Coumoul X, Barouki R. Génotoxicité des métabolites des oestrogènes et cancers. Med Sci 2002; 18: 86–90. [Google Scholar]
  16. Turgeon D, Carrier JS, Lévesque E, Beatty BG, Bélanger A, Hum DW. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. J Mol Biol 2000; 295: 489–504. [Google Scholar]
  17. Lévesque E, Beaulieu M, Green MD, Tephly TR, Bélanger A, Hum DW. Isolation and characterization of UGT2B15(Y85): A UDPglucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 1997; 7: 317–25. [Google Scholar]
  18. Beaulieu M, Lévesque E, Hum DW, Bélanger A. Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids. J Biol Chem 1996; 271: 22855–62. [Google Scholar]
  19. Horton R. Dihydrotestosterone is a peripheral paracrine hormone. J Androl 1992; 13: 23–7. [Google Scholar]
  20. Bélanger A, Couture J, Caron S, Roy R. Determination of nonconjugated and conjugated steroid levels in plasma and prostate after separation on C-18 columns. Ann NY Acad Sci 1990; 595: 251–9. [Google Scholar]
  21. El-Alfy M, Luu-The V, Huang XF, Berger L, Labrie F, Pelletier G. Localization of type 5 17betahydroxysteroid dehydrogenase, 3betahydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunohistochemistry. Endocrinology 1999; 140: 1481–91. [Google Scholar]
  22. Barbier O, Lapointe H, El Alfy M, Hum DW, Belanger A. Cellular localization of uridine diphosphoglucuronosyltran sferase 2B enzymes in the human prostate by in situ hybridization and immunohistochemistry. J Clin Endocrinol Metab 2000; 85: 4819–26. [Google Scholar]
  23. MacLeod SL, Nowell S, Plaxco J, Lang NP. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDPglucuronosyltransferase 2B15 gene in a casecontrol study of prostate cancer. Ann Surg Oncol 2000; 7: 777–82. [Google Scholar]
  24. Gsur A, Preyer M, Haidinger G, et al. A polymorphism in the UDPglucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2002; 11: 497–8. [Google Scholar]

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