Free Access
Issue
Med Sci (Paris)
Volume 19, Number 2, Février 2003
Page(s) 217 - 222
Section M/S Revues
DOI https://doi.org/10.1051/medsci/2003192217
Published online 15 February 2003
  1. Bar-Sagi D, Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103: 227–38. [Google Scholar]
  2. Katzav S, Martin-Zanca D, Barbacid M. Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J 1989; 8: 2283–90. [Google Scholar]
  3. Schuebel KE, Bustelo XR, Nielsen DA, et al. Isolation and characterization of murine vav2, a member of the vav family of protooncogenes. Oncogene 1996; 13: 363–71. [Google Scholar]
  4. Movilla N, Bustelo XR. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol Cell Biol 1999; 19: 7870–85. [Google Scholar]
  5. Bustelo XR. Regulatory and signaling properties of the Vav family. Mol Cell Biol 2000; 20: 1461–77. [Google Scholar]
  6. Collins TL, Deckert M, Altman A. Views on Vav. Immunol Today 1997; 18: 221–5. [Google Scholar]
  7. Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. Phosphotyrosinedependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 1997; 385: 169–72. [Google Scholar]
  8. Aghazadeh B, Lowry WE, Huang XY, Rosen, MK. Structural basis for relief of autoinhibition of the Dbl homology domain of protooncogene Vav by tyrosine phosphorylation. Cell 2000; 102: 625–33. [Google Scholar]
  9. Han J, Luby-Phelps K, Das B, et al. Role of substrates and products of PI 3- kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 1998; 279: 558–60. [Google Scholar]
  10. Das B, Shu X, Day GJ, et al. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem 2000; 275: 15074–81. [Google Scholar]
  11. Djouder N, Schmidt G, Frings M, Cavalie A, Thelen M, Aktories K. Rac and phosphatidylinositol 3- kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. J Immunol 2001; 166: 1627–34. [Google Scholar]
  12. Inabe K, Ishiai M, Scharenberg AM, Freshney N, Downward J, Kurosaki T. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med 2002; 195: 189–200. [Google Scholar]
  13. Schuebel KE, Movilla N, Rosa JL, Bustelo XR. Phosphorylationdependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J 1998; 17: 6608–21. [Google Scholar]
  14. Fischer KD, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, Guidos C. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature 1995; 374: 474–7. [Google Scholar]
  15. Kong YY, Fischer KD, Bachmann MF, et al. Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med 1998; 188: 2099–111. [Google Scholar]
  16. Costello PS, Walters AE, Mee PJ, et al. The Rhofamily GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NFkappaB pathways. Proc Natl Acad Sci USA 1999; 96: 3035–40. [Google Scholar]
  17. Penninger JM, Fischer KD, Sasaki T, et al. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated costimulation. Eur J Immunol 1999; 29: 1709–18. [Google Scholar]
  18. Dood GM, Bell SE, Vigorito E, et al. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol 2001; 2: 542–7. [Google Scholar]
  19. Tedford K, Nitschke L, Girkontaite I, et al. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol 2001; 2: 548–55. [Google Scholar]
  20. Krawczyk C, Penninger JM. Molecular motors involved in T cell receptor clusterings. J Leuk Biol 2001; 69: 317–30. [Google Scholar]
  21. Kaminuma O, Deckert M, Elly C, Liu YC, Altman A. Vav-Rac1-mediated activation of the c-Jun Nterminal kinase/c-Jun/AP- 1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. Mol Cell Biol 2001; 21: 3126–36. [Google Scholar]
  22. Charvet C, Auberger P, Tartare-Deckert S, Bernard A, Deckert M. Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEKdependent pathway. J Biol Chem 2002; 277: 15376–84. [Google Scholar]
  23. Doody GM, Billadeau DD, Clayton E. Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J 2000; 19: 6173–84. [Google Scholar]
  24. Tartare-Deckert S, Monthouel MN, Charvet C, et al. Vav2 activates c-fos serum response element and CD69 expression, but negatively regulates NF-AT and IL-2 gene activation in T lymphocyte. J Biol Chem 2001; 276: 20849–57. [Google Scholar]
  25. Fackler OT, Lu X, Frost JA, et al. p21-activated kinase 1 plays a critical role in cellular activation by Nef. Mol Cell Biol 2000; 20: 2619–27. [Google Scholar]
  26. Mahana W, Zhao TM., Teller R, Robinson MA, Kindt TJ. Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells. Proc Natl Acad Sci USA 1998; 95: 1782–7. [Google Scholar]
  27. Chiang YJ, Kole HK, Brown K, et al. Cbl-b regulates the CD28 dependence of Tcell activation. Nature 2000; 403: 216–20. [Google Scholar]
  28. Krawczyk C, Bachmaier K, Sasaki T, et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 2000; 13: 463–73. [Google Scholar]

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