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Tableau I.
Exemples de cardiomyopathies modélisées chez la drosophile. Les mutations entraînent des cardiomyopathies chez l’homme et affectent des gènes conservés codant des protéines du sarcomère. CMH : cardiomyopathie hypertrophique ; CMD : cardiomyopathie dilatée ; CMR : cardiomyopathie restrictive.
| Protéine | Gène humain | Cardiomyopathie | Gène drosophile (symbole) | Modélisation chez la drosophile | Références |
|---|---|---|---|---|---|
| Myosine, chaîne lourde β | MYH7 | CMH, CMD, CMR | Myosin heavy chain (Mhc) | CMD, CMR | [17] |
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| Tropomyosine | TPM1 | CMH, CMD | Tropomyosin 1 et 2 (Tm1, Tm2) | CMD | [11] |
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| Troponine T | TNNT2 | CMH, CMD, CMR | upheld (up) | CMR | [17] |
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| Troponine I | TNNI3 | CMH, CMD, CMR | wings up A (wupA) | CMD | [11] |
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| δ sarcoglycan | SGCD | CMD | Sarcoglycan d (Scg d) | CMD | [18, 19] |
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| Dystrophine | DMD | CMD | Dystrophine (Dys) | CMD | [20, 21] |
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| Crystalline, Alpha B | CRYAB | CMD | lethal (2) essential for life (l[2]efl) | CMD | [22] |
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