Tableau I.
Caractéristiques des Nox et mécanismes de régulation . Facteurs cytosoliques organisateurs : p40phox, p47phox, NoxO1. Facteurs activateurs : p67phox, NoxA1. CDHD : catalytic deshydrogenase domain; REHBD : regulatory EF-hand binding domain; PhosR : segment phosphorylable; CaM : calmoduline; PDI : protein disulfide isomerase; TLR4 : Toll-like receptor 4; Poldip2 : DNA polymerase delta interaction protein 2; NQO-1 : NA(D)PH quinone oxidoreductase-1; Pin1 : prolyl-6-trans-isomerase; TKS : tyrosine kinase substrat; 6PGDH : 6-phosphogluconate deshydrogenase; P : phosphate; VSMC : vascular smooth muscle cells.
| Isoenzymes (chromosome, chr) | Identité versus Nox2 | Variants | Association avec p22phox | Activation | Sites et état de glycosylation | Changement conformationnel Repliement | Régulation | |
|---|---|---|---|---|---|---|---|---|
| Nox1 (chr X) | 56 % | 2 | Oui | Assemblage NoxO1, NoxA1, Rac1 | 2 | Non | Boucle B Û CDHD | NoxA1-P ↘ |
| NoxO1-P ↗ | ||||||||
| TKS4, TKS5 | ||||||||
| Nox2 (chr X) | 100 % | 3 | Oui | Assemblage p47phox, p67phox, p40phox, Rac2 | 3 | Oui | Boucle B Û CDHD | Allostérie : p67phox/S100A8 ↗ |
| 6PGDH ↗ | ||||||||
| Pin1 ↗ | ||||||||
| Nox2-P | ||||||||
| p47phox-P/p40phox-P/p67phox-P | ||||||||
| Nox3 (chr 6) | 58 % | (-) | Oui | Assemblage NoxO1, NoxA1, Rac1 ? | 1 | Oui | Boucle B Û CDHD | NoxA1 |
| Phosphorylation ? | ||||||||
| TKS4, TKS5 | ||||||||
| Nox4 (chr 6) | 37 % | 5 | Oui | Activité constitutive | 2 | Oui | Boucle B Û CDHD | Poldip2 (VSMC) ↗ |
| HO-1 ↘ | ||||||||
| Quinones/NQ01 ↗ | ||||||||
| PDI ↗ | ||||||||
| TLR4 ↗ | ||||||||
| Nox5 (chr 15) | 27 % | 6 | Non | Ca++ | - | Non | Nox5-EF Û REHBD/PhosR Levée d’inhibition | Nox5-P => ↗ sensibilité Ca++ |
| Allostérie CaM/Ca++ | ||||||||
| Duox1/2 (chr 15) | (-) | Non | Ca++ Û NoxA1 poumon | Plusieurs | Oui | Levée d’inhibition | Duox1/2-P => ↗ sensibilité Ca++ | |
| DuoxA1/DuoxA2 | ||||||||
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.