Figure 1.
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Structure de l’inflammasome. A.. Structure des domaines composant l’inflammasome. B. L’inflammasome NLRP3 est composé du récepteur NLRP3, de l’adaptateur ASC et de la procaspase-1. PYD : pyrin domain ; NBD : nucleotide binding domain (permet l’oligomérisation dépendante de l’ATP des NLR) ; LRR : leucine-rich repeats ; FIIND : function to find domain ; CARD : caspase activation and recruitment domain ; RD : repression domain.
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