Figure 4.
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Pharmacologie de l’action induite par le récepteur CTLA-4. CPA : cellule présentatrice d’antigène ; TRIM : T-cell receptor-interacting molecule ; TGN : trans-Golgi network ; PLD : phospholipase D ; ARF : adenosine diphosphate (ADP)-ribosylation factor ; AP : adapter protein ; PI3K : phosphatidylinositol 3’-kinase ; SHP2 : SH2-domain-containing protein tyrosine phosphatase 1 ; PP2A : protein phosphatase 2A ; Lck : lymphocyte cellular kinase ; Fyn : Fgr/yes-related novel gene ; RLK : receptor-like kinases (d’après [11]).
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