Free Access

Figure 3.


Télécharger l'image originale

Fonction inhibitrice de CTLA-4. Dans un contexte de reconnaissance antigénique, les signaux de costimulation via CD28 (ici PI3K-indépendant) peuvent être inhibés par l’intervention de CTLA-4. ZAP-70 : zeta-chain-associated protein kinase of 70 kDa ; LAT : linker of activation in T cell ; SLP-76 : SH2-domain-containing leukocyte protein of 76 kDa ; PKC θ : protein kinase C θ  ; CARMA1 : caspase recruitment domain (CARD)-containing membrane-associated guanylate kinase (MAGUK) protein-1 ; cSMAC : central supramolecular activation cluster.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.