Figure 2.
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Pharmacologie PI3K-indépendante induite par CD28. Les différentes protéine kinase/molécules adaptatrices recrutées au niveau du domaine intracytoplasmique de CD28 sont représentées, ainsi que leurs cibles effectrices. PI3K : phosphatidylinositol 3’-kinase ; Lck : lymphocyte cellular kinase ; PDK-1 : phosphoinositide-dependent protein kinase 1 ; PKC θ : protein kinase C θ ; GSK3b : glycogen synthetase kinase 3B ; Grb2 : growth factor receptor-bound protein 2 ; FLNA : filamin A ; Vav : vav proto-oncogene ; LAT : linker of activation in T cell ; SLP-76 : SH2-domain-containing leucocyte protein of 76 kDa ; PLC-g1 : phospholipase c g-1 ; DAG : diacyl glycerol ; PKC θ : protein kinase C θ ; CARMA1 : caspase recruitment domain (CARD)-containing membrane-associated guanylate kinase (MAGUK) protein-1 ; Bcl10 : B-cell lymphoma/leukemia 10 ; MALT1 : mucosa-associated lymphoma translocation protein 1 ; CaN : calcineurin ; Sos : son of sevenless ; Cdc42 : cell division cycle 42 ; Rac1 : Ras-related C3 botulinum toxin substrate 1 ; JNK : jun kinase ; AP1 : activator protein 1 ; NFAT : nuclear factor of activated T-cells ; NFκB : nuclear factor kappa B.
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