| Issue |
Med Sci (Paris)
Volume 40, Number 11, Novembre 2024
Chroniques génomiques
|
|
|---|---|---|
| Page(s) | 869 - 871 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2024149 | |
| Published online | 10 December 2024 | |
L’édition de nouvelle génération
New-generation editing
Biologiste, généticien et immunologiste, Président d’Aprogène (Association pour la promotion de la Génomique), 13007 Marseille, France
Abstract
Recent work on bacterial insertion sequences reveals that some of them use an RNA sequence (called Bridge RNA or Seek RNA) to define both donor and target DNA specificity. This opens the way to easy insertion of kilobase DNA sequences at pre-defined sites in the genome, announcing a host of new possibilities. The system still needs a lot of tweaking, as it has only been demonstrated in bacteria, but it holds great promise for genome editing and engineering.
© 2024 médecine/sciences – Inserm
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