| Issue |
Med Sci (Paris)
Volume 35, Number 8-9, Août–Septembre 2019
|
|
|---|---|---|
| Page(s) | 709 - 711 | |
| Section | Forum | |
| DOI | https://doi.org/10.1051/medsci/2019136 | |
| Published online | 18 September 2019 | |
Les pièges de l’amélioration
Chroniques génomiques
Enhancement can do harm
UMR 7268 ADÉS, Aix-Marseille, Université /EFS/CNRS; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France
Abstract
Inactivation of the CCR5 gene by CRISPR editing in human embryos, as recently attempted in China, was touted as a positive change for the babies involved since it was expected to impart resistance to HIV infection. However, it turns out that the absence of CCR5 is not neutral but actually decreases fitness, as shown by survival analysis of population data in the UK biobank. This underlines the pitfalls of genetic enhancement, and emphasizes that any germline modification must be preceded by in-depth studies to exclude unforeseen negative effects. ‡
© 2019 médecine/sciences – Inserm
Article publié sous les conditions définies par la licence Creative Commons Attribution License CC-BY (http://creativecommons.org/licenses/by/4.0), qui autorise sans restrictions l'utilisation, la diffusion, et la reproduction sur quelque support que ce soit, sous réserve de citation correcte de la publication originale.
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