Med Sci (Paris)
Volume 34, October 2018Cancer biomarkers
|Page(s)||4 - 7|
|Published online||07 November 2018|
Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase
Department of pharmacy, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China
2 Department of Traditional Chinese Medicine, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China
3 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P.R. China
4 Department of Nephrology, Lishui People’s Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China
Corresponding authors: Zhihong Gui and Weihua Chu firstname.lastname@example.org
Objective: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China.
Methods: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed.
Results: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice.
Conclusion: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.
Key words: Liuwei Dihuang / antidiabetic effects / α-amylase / α-glucosidase
© 2018 médecine/sciences – Inserm
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