Med Sci (Paris)
Volume 31, Number 11, Novembre 2015
|Page(s)||1035 - 1038|
|Published online||17 November 2015|
CRISPR-Cas9, une nouvelle donne pour la thérapie génique
CRISPR-Cas9, a new chance for somatic gene therapy
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d’adultes la Timone, 264, rue Saint-Pierre, 13385
Marseille Cedex 05, France
CoReBio PACA, case 901, parc scientifique de Luminy, 13288
Marseille Cedex 09, France
Targeted modification of genes (“gene editing”) is made much easier by the recently developed CRISPR-Cas9 system. This has raised alarm about possible uses of this technology for germline modification of the human genome; however this technology has less controversial applications, notably for somatic gene therapy with already some striking demonstrations in animal systems. Because of its precision and relative ease of use, CRISPR can be expected to drive a revolution in gene therapy and to turn it into a more mainstream approach.
© 2015 médecine/sciences – Inserm
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