Issue |
Med Sci (Paris)
Volume 30, Number 8-9, Août–Septembre 2014
|
|
---|---|---|
Page(s) | 790 - 796 | |
Section | M/S Revues | |
DOI | https://doi.org/10.1051/medsci/20143008018 | |
Published online | 01 September 2014 |
Rôle des longs ARN non codants dans le développement normal et pathologique
Functions of lncRNA in development and diseases
1
Inserm UMR1090 TAGC (technological advances for genomics and clinics), 13288
Marseille, France
2
Université Aix-Marseille, UMR1090 TAGC, 13288
Marseille, France
3
Polytech Marseille, parc scientifique de Luminy, Marseille, France
*
salvatore.spicuglia@inserm.fr
Des analyses génomiques à grande échelle ont mis en évidence l’existence d’une multitude de longs ARN non codants (lncRNA). Bien que la fonction de la majorité de ces lncRNA reste à l’heure actuelle inexplorée, il semble clair que plusieurs de ces transcrits jouent un rôle important dans la régulation de l’expression génique et sont impliqués dans diverses pathologies, notamment le cancer. De fait, des études fonctionnelles ont démontré la participation des lncRNA à divers processus physiologiques. Cette revue résume les connaissances actuelles sur la biologie des lncRNA et sur leurs fonctions dans le développement normal et pathologique chez les mammifères.
Abstract
The transcription of essentially the entire eukaryotic genome generates a myriad of non-coding RNA species that show complex overlapping patterns of expression and regulation. In the last decade, several large scale genomic analyses have shed light on the widespread existence of long non-coding RNAs (lncRNAs) in mammals. Although the function of most lncRNAs remains unknown, many of them have been suggested to play important roles in the regulation of gene expression during normal development and diseases, including cancers. Indeed, functional studies have demonstrated that lncRNAs participate in various biological processes, including reprogramming of pluripotent stem cells, oncogenic progression and cell cycle regulation. In this review, we summarize recent findings about the biology of lncRNAs and their functions in normal and pathological development in mammals.
© 2014 médecine/sciences – Inserm
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.