Issue |
Med Sci (Paris)
Volume 19, Number 10, Octobre 2003
|
|
---|---|---|
Page(s) | 920 - 925 | |
Section | M/S Revues | |
DOI | https://doi.org/10.1051/medsci/20031910920 | |
Published online | 15 October 2003 |
La voie de signalisation PATCHED/Sonic Hedgehog dans le cancer superficiel de la vessie
The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer
Centre de recherche en cancérologie de l’Université Laval, CHUQ-L’Hôtel-Dieu de Québec, 10, rue MacMahon, G1R 2J6 Québec, Canada
Le cancer de la vessie se présente sous deux formes différentes: la forme superficielle et la forme infiltrante. La forme superficielle se caractérise par une fréquence élevée de pertes (totales ou partielles) du chromosome 9, notamment du bras long. Ces observations suggèrent la présence de gènes suppresseurs de tumeur (GST) dans cette région. Nous présentons le gène PATCHED, localisé en position 9q22.3, déjà impliqué dans le carcinome basocellulaire de la peau, comme un GST potentiel dans le cancer superficiel de la vessie.
Abstract
Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.
© 2003 médecine/sciences - Inserm / SRMS
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