La voie de signalisation PATCHED/Sonic Hedgehog dans le cancer superficiel de la vessie

Hélène LaRue; Maryse Simoneau; Tahar O. Aboulkassim; Patricia Lemieux; Johanne Girard; Sahar Hamed; Hélène Hovington; Lucie Jeannotte; Yves Fradet

doi:10.1051/medsci/20031910920

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Volume 19 / Numéro 10 (Octobre 2003)

Med Sci (Paris), 19 10 (2003) 920-925

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Numéro		Med Sci (Paris) Volume 19, Numéro 10, Octobre 2003


Page(s)		920 - 925
Section		M/S Revues
DOI		https://doi.org/10.1051/medsci/20031910920
Publié en ligne		15 octobre 2003

Knowles MA. The genetics of transitional cell carcinoma: progress and potential clinical application. BJU Int 1999; 84: 412–27. [Google Scholar]
Simoneau M, Aboulkassim TO, Larue H, Rousseau F, Fradet Y. Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31. Oncogene 1999; 18: 157–63. [Google Scholar]
Czerniak B, Chaturvedi V, Li L, et al. Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. Oncogene 1999; 18: 1185–96. [Google Scholar]
Williams SV, Sibley KD, Davies AM, et al. Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines. Genes Chrom Cancer 2002; 34: 86–96. [Google Scholar]
Bartlett JMS, Watters AD, Ballantyne SA, Going JJ, Grigor KM, Cooke TG. Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder ? Br J Cancer 1998; 77: 2193–8. [Google Scholar]
Simoneau M, Larue H, Aboulkassim TO, Meyer F, Moore L, Fradet Y. Chromosome 9 deletions and recurrence of superficial bladder cancer: identification of four regions of prognostic interest. Oncogene 2000; 19: 6317–23. [Google Scholar]
Aboulkassim TO, Larue H, Lemieux P, Rousseau F, Fradet Y. Alteration of the Patched locus in superficial bladder cancer. Oncogene 2003; 22: 2967–71. [Google Scholar]
Wicking C, Smyth I, Bale A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene 1999; 18: 7844–51. [Google Scholar]
Bale AE, Yu KP. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 2001; 10: 757–62. [Google Scholar]
Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 1996; 10: 301–12. [Google Scholar]
Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000; 67: 1047–54. [Google Scholar]
Altaba A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 1999; 126: 3205–16. [Google Scholar]
Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature 2002; 417: 299–304. [Google Scholar]
Yoon JW, Kita Y, Frank DJ, et al. Gene expression profiling leads to identification of GLI1- binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002; 277: 5548–55. [Google Scholar]
McGarvey TW, Maruta Y, Tomaszewski JE, Linnenbach AJ, Malkowicz SB. PTCH gene mutations in invasive transitional cell carcinoma of the bladder. Oncogene 1998; 17: 1167–72. [Google Scholar]
Simoneau AR, Spruck CH 3rd, Gonzalez-Zulueta M, et al. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res 1996; 56: 5039–43. [Google Scholar]
Xie J, Johnson RL, Zhang X, et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res 1997; 57: 2369–72. [Google Scholar]
Ohgaki K, Minobe K, Kurose K, et al. Two target regions of allelic loss on chromosome 9 in urinarybladder cancer. Jpn J Cancer Res 1999; 90: 957–64. [Google Scholar]
Velickovic M, Delahunt B, McIver B, Grebe SK. Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. Mod Pathol 2002; 15: 479–85. [Google Scholar]
Xu X, Brodie SG, Yang X, et al. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 2000; 19: 1868–74. [Google Scholar]
Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 2001; 264: 148–68. [Google Scholar]
Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chrom Cancer 2000; 28: 77–81. [Google Scholar]

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[1] Knowles MA. The genetics of transitional cell carcinoma: progress and potential clinical application. BJU Int 1999; 84: 412–27. [Google Scholar]

[2] Simoneau M, Aboulkassim TO, Larue H, Rousseau F, Fradet Y. Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31. Oncogene 1999; 18: 157–63. [Google Scholar]

[3] Czerniak B, Chaturvedi V, Li L, et al. Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. Oncogene 1999; 18: 1185–96. [Google Scholar]

[4] Williams SV, Sibley KD, Davies AM, et al. Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines. Genes Chrom Cancer 2002; 34: 86–96. [Google Scholar]

[5] Bartlett JMS, Watters AD, Ballantyne SA, Going JJ, Grigor KM, Cooke TG. Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder ? Br J Cancer 1998; 77: 2193–8. [Google Scholar]

[6] Simoneau M, Larue H, Aboulkassim TO, Meyer F, Moore L, Fradet Y. Chromosome 9 deletions and recurrence of superficial bladder cancer: identification of four regions of prognostic interest. Oncogene 2000; 19: 6317–23. [Google Scholar]

[7] Aboulkassim TO, Larue H, Lemieux P, Rousseau F, Fradet Y. Alteration of the Patched locus in superficial bladder cancer. Oncogene 2003; 22: 2967–71. [Google Scholar]

[8] Wicking C, Smyth I, Bale A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene 1999; 18: 7844–51. [Google Scholar]

[9] Bale AE, Yu KP. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet 2001; 10: 757–62. [Google Scholar]

[10] Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 1996; 10: 301–12. [Google Scholar]

[11] Villavicencio EH, Walterhouse DO, Iannaccone PM. The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 2000; 67: 1047–54. [Google Scholar]

[12] Altaba A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 1999; 126: 3205–16. [Google Scholar]

[13] Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature 2002; 417: 299–304. [Google Scholar]

[14] Yoon JW, Kita Y, Frank DJ, et al. Gene expression profiling leads to identification of GLI1- binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002; 277: 5548–55. [Google Scholar]

[15] McGarvey TW, Maruta Y, Tomaszewski JE, Linnenbach AJ, Malkowicz SB. PTCH gene mutations in invasive transitional cell carcinoma of the bladder. Oncogene 1998; 17: 1167–72. [Google Scholar]

[16] Simoneau AR, Spruck CH 3rd, Gonzalez-Zulueta M, et al. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res 1996; 56: 5039–43. [Google Scholar]

[17] Xie J, Johnson RL, Zhang X, et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res 1997; 57: 2369–72. [Google Scholar]

[18] Ohgaki K, Minobe K, Kurose K, et al. Two target regions of allelic loss on chromosome 9 in urinarybladder cancer. Jpn J Cancer Res 1999; 90: 957–64. [Google Scholar]

[19] Velickovic M, Delahunt B, McIver B, Grebe SK. Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. Mod Pathol 2002; 15: 479–85. [Google Scholar]

[20] Xu X, Brodie SG, Yang X, et al. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 2000; 19: 1868–74. [Google Scholar]

[21] Philipp-Staheli J, Payne SR, Kemp CJ. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 2001; 264: 148–68. [Google Scholar]

[22] Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chrom Cancer 2000; 28: 77–81. [Google Scholar]