Issue |
Med Sci (Paris)
Volume 18, Number 10, Octobre 2002
|
|
---|---|---|
Page(s) | 975 - 981 | |
Section | M/S Revues : Articles de Synthèse | |
DOI | https://doi.org/10.1051/medsci/20021810975 | |
Published online | 15 October 2002 |
De nouveaux rôles pour l’ADN topo-isomérase I
New roles for DNA topoisomerase I
Laboratoire de Pharmacologie des agents anti-cancéreux, Institut Bergonié, 229, cours de l’Argonne, 33076 Bordeaux Cedex, France
L’ADN topo-isomérase I eucaryote est une enzyme nucléaire dont le rôle essentiel est de supprimer les contraintes de torsion de l’ADN au cours des processus de réplication et de transcription. La découverte de son activité de protéine kinase, de sa grande similitude avec des enzymes de recombinaison de l’ADN, et de sa capacité de « reconnaître » une grande variété de lésions de l’ADN, a permis d’envisager de nouveaux rôles pour cette enzyme. Nous discuterons en particulier le rôle potentiel de la topo-isomérase I dans la signalisation des dommages de l’ADN aux systèmes de mort cellulaire.
Abstract
DNA topoisomerase I is an nuclear enzyme involved in multiple DNA transactions such as replication, transcription and chromosome condensation. Besides its activity of DNA relaxation, that is essential for the removal of torsional constraints associated with these processes, topoisomerase I may have other functions related to its kinase activity, its similarity with DNA recombinases, and its ability to be trapped by various DNA modifications. In this review, recent findings on the poisoning of topoisomerase I by a broad range of DNA lesions are discussed in the context of a possible role of the enzyme in DNA damage signalling to the cell death machinery.
© 2002 médecine/sciences - Inserm / SRMS
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